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Jonathan Lin

Jonathan Lin

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Education:

B.S. Chemical biology, B.A. Music, UC Berkeley 2017

From:  San Jose, CA

Joined the David Lab: January 2018

Outside of lab: Music and the ergometer

 

 

Research in the David Lab

Oxidative damage to DNA can cause genetic mutations that lead to cancer. A lack of activity by DNA repair enzymes such as glycosylases deters the removal of these damaged DNA base pairs. Using synthetic methods, I develop nucleoside/nucleotide analogues that will serve as inhibitors of various DNA glycosylases. Doing so will allow us to “trap” these enzymes in action, in vitro and potentially in vivo, for structural and enzymatic studies. In addition, these analogues may be used to help develop pharmaceuticals to fight cancer.

Previous Research Experience:

As a visiting researcher in Dr. Ken Wong’s lab at the National Cheng-Kung University Medical School (Tainan, Taiwan), I sought after a non-invasive method to detect the onset of squamous cell carcinoma in dystrophic epidermolysis bullosa patients through analysis of patients’ wound fluids.

 

 

RSS Science Daily News

  • One shot, seven days: Long-acting levodopa gel tackles Parkinson’s tremors July 14, 2025
    Researchers in Australia have created a biodegradable gel that delivers Parkinson’s medications through a single weekly shot, replacing the need for multiple daily pills. Injected just under the skin, the gel steadily releases levodopa and carbidopa for seven days, helping keep tremors and stiffness in check while easing side effects linked to fluctuating doses.
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    Zebrafish can regenerate sensory hair cells that humans permanently lose, like those in the inner ear linked to hearing and balance. New research reveals two specific genes that control how different supporting cells in zebrafish divide and regenerate, offering clues to how mammals might someday tap into similar regenerative powers.
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  • This AI-powered lab runs itself—and discovers new materials 10x faster July 14, 2025
    A new leap in lab automation is shaking up how scientists discover materials. By switching from slow, traditional methods to real-time, dynamic chemical experiments, researchers have created a self-driving lab that collects 10 times more data, drastically accelerating progress. This new system not only saves time and resources but also paves the way for faster […]
  • This Algorithm Just Solved One of Physics’ Most Infamous Problems July 14, 2025
    Using an advanced Monte Carlo method, Caltech researchers found a way to tame the infinite complexity of Feynman diagrams and solve the long-standing polaron problem, unlocking deeper understanding of electron flow in tricky materials.

Contact:

Dr. Sheila S. David
ssdavid@ucdavis.edu
(530)-752-4280

Department of Chemistry
One Shields Ave.
Davis, CA 95616