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Jonathan Lin

Jonathan Lin

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Education:

B.S. Chemical biology, B.A. Music, UC Berkeley 2017

From:  San Jose, CA

Joined the David Lab: January 2018

Outside of lab: Music and the ergometer

 

 

Research in the David Lab

Oxidative damage to DNA can cause genetic mutations that lead to cancer. A lack of activity by DNA repair enzymes such as glycosylases deters the removal of these damaged DNA base pairs. Using synthetic methods, I develop nucleoside/nucleotide analogues that will serve as inhibitors of various DNA glycosylases. Doing so will allow us to “trap” these enzymes in action, in vitro and potentially in vivo, for structural and enzymatic studies. In addition, these analogues may be used to help develop pharmaceuticals to fight cancer.

Previous Research Experience:

As a visiting researcher in Dr. Ken Wong’s lab at the National Cheng-Kung University Medical School (Tainan, Taiwan), I sought after a non-invasive method to detect the onset of squamous cell carcinoma in dystrophic epidermolysis bullosa patients through analysis of patients’ wound fluids.

 

 

RSS Science Daily News

  • New Orleans is sinking—and so are its $15 billion flood defenses June 29, 2025
    Parts of New Orleans are sinking at alarming rates — including some of the very floodwalls built to protect it. A new satellite-based study finds that some areas are losing nearly two inches of elevation per year, threatening the effectiveness of the city's storm defenses.
  • Record-breaking 10-billion-year radio halo just rewrote the universe’s origin story June 28, 2025
    A newly discovered radio halo, 10 billion light-years away, reveals that galaxy clusters in the early universe were already steeped in high-energy particles. The finding hints at ancient black hole activity or cosmic particle collisions fueling this energy.
  • A mysterious mineral in asteroid Ryugu may rewrite planetary history June 28, 2025
    A surprising discovery from a tiny grain of asteroid Ryugu has rocked scientists' understanding of how our Solar System evolved. Researchers found djerfisherite—a mineral typically born in scorching, chemically reduced conditions and never before seen in Ryugu-like meteorites—inside a sample returned by Japan’s Hayabusa2 mission. Its presence suggests either Ryugu once experienced unexpectedly high temperatures […]
  • A giant pulse beneath Africa could split the continent — and form an ocean June 27, 2025
    Beneath the Afar region in Ethiopia, scientists have discovered pulsing waves of molten rock rising from deep within the Earth — a geological heartbeat that could eventually split Africa in two. These rhythmic surges of mantle material are helping to stretch and thin the continent’s crust, setting the stage for a new ocean to form […]
  • World’s largest camera just snapped the Universe in 3,200 megapixels June 27, 2025
    The LSST camera at the Vera C. Rubin Observatory has released its jaw-dropping first images, each capturing 45 times the area of the full moon in one shot. Over the next ten years, this cosmic giant will scan the southern sky in ultra-HD, helping scientists uncover everything from asteroids to the secrets of dark energy.

Contact:

Dr. Sheila S. David
ssdavid@ucdavis.edu
(530)-752-4280

Department of Chemistry
One Shields Ave.
Davis, CA 95616