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Welcome to the David Lab Website!
The David Lab at UC Davis utilizes numerous tools of chemical biology to explore the complex mechanistic details of DNA repair enzymes. DNA repair proteins such as MutY and NEIL, among the targets of research of the David Lab, help catalyze necessary repair of oxidative DNA damage, and are critical to maintaining genomic integrity in organisms living in the oxygen-rich environment of Earth. The David Lab is headed by Dr. Sheila S. David, who has led at the forefront of DNA repair research for over 25 years. The David Lab continues to push forward the world’s current understanding of DNA repair enzymes by leveraging our unique expertise in DNA repair enzymology while venturing into new areas and collaborating with scientists around the world.
Featured Article:
When you’re strange: Unusual features of the MUTYH glycosylase and implications in cancer.
Think MUTYH is a simple adenine glycosylase? Think again. Explore the dizzying diversity of MUTYH interactions to DNA damage response proteins and their implications in cancer in our lab’s newest review by Alan Raetz and Sheila David.
https://doi.org/10.1016/j.dnarep.2019.05.005
Raetz, A.G.; David, S.S. When you’re strange: Unusual features of the MUTYH glycosylase and implications in cancer. DNA Repair. 2019, 80, 16-25.
Recent Articles:
Featured Photos:
ACS Chemical Biology LiveSlides Presentation:
Structure–Activity Relationships Reveal Key Features of 8-Oxoguanine: A Mismatch Detection by the MutY Glycosylase
Listen in while Chandrima Majumdar explains this recent work from the David Lab, which was selected as an ACS Editor’s Choice article.
For the latest David Lab updates, check out the News section.
Click on Research for an overview of The David Lab’s research.
A thorough list of publications is available in the Publications section. t the News section.
Click on Research for an overview of The David Lab’s research.
A thorough list of publications is available in the Publications section.
Research in the David Lab:
Graduate Student Spotlight
Introducing the David Lab Graduate Student Spotlight! Check out our conversation with Nicole as she discusses her journey as a Ph.D. student working in the David Lab.
Undergraduate Student Spotlight
Meet UC Davis Undergraduate Researcher Madeline Bright in our lab’s new Undergraduate Student Spotlight Video!
David Lab FYI Video
How to efficiently pour column fractions: Run a column <60 min.
Doing this will greatly increase your already-existing love of columns. And your productivity.
Get the most out of your flash column. It’s not called slow column chromatography.
Use this information at your own risk. This video is intended for graduate / professional level researchers. Be sure to follow your lab’s safety protocols.
Video by Robert Van Ostrand.
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David Lab Members
The David Lab – April 2019
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Keywords: #DavidLab #TheDavidLab #UCDavis #DNA #DNARepair #Muty #Mutyh #8OG #enzymes #ModifiedOligonucleotides #ModifiedNucleosides #OrganicSynthesis #Synthesis #BaseExcisionRepair #BER #NEIL #ChemicalBiology #Chemistry #SheilaDavid #UCDavisChemistry #glycosylase