Welcome to the David Lab Website!

The David Lab at UC Davis utilizes numerous tools of chemical biology to explore the complex mechanistic details of DNA repair enzymes. DNA repair proteins such as MutY and NEIL, among the targets of research of the David Lab, help catalyze necessary repair of oxidative DNA damage, and are critical to maintaining genomic integrity in organisms living in the oxygen-rich environment of Earth. The David Lab is headed by Dr. Sheila S. David, who has led at the forefront of DNA repair research for over 25 years. The David Lab continues to push forward the world’s current understanding of DNA repair enzymes by leaning on its unique expertise with chemical synthesis and enzyme kinetics experiments.

Featured Articles:

Featured Photos:

Holly's Handprint Ceremony

Holly says goodbye to Sheila and Chandrima.

Doug & Sheila - DEB Chalk Talk - Oct. 30, 2017

Doug and Sheila take a pause for a photo at Doug's D.E.B. Chalk Talk, discussing one of Doug's favorite DNA repair proteins, MUTYH, in his talk titled, "Elucidation of the role of DNA glycosylase MUTYH in a cell death response to alkylating agents."

CCB-GAP Poster Session 2017

Jazmin Stenson discusses her summer project work in the David Lab at the ChemEnergy REU & CCB-GAP Poster Session.

David-Beal Lab Kickball Game 2017

The David/Beal Lab Kickball Game: The Beal Lab won the trophy back this year - but we will be looking to bring it back to its rightful home in 2018!

ACS Chemical Biology LiveSlides Presentation: 

Structure–Activity Relationships Reveal Key Features of 8-Oxoguanine: A Mismatch Detection by the MutY Glycosylase

Listen in while Chandrima Majumdar explains this recent work from the David Lab, which was selected as an ACS Editor’s Choice article.

For the latest David Lab updates, check out the News section.

Click on Research for an overview of The David Lab’s research.

A thorough list of publications is available in the Publications section. t the News section.

Click on Research for an overview of The David Lab’s research.

A thorough list of publications is available in the Publications section.

Research in the David Lab:

Bacteria inoculation for protein preparation

Chandrima inoculates bacteria culture during her MutY protein preparation.

Synthetic compound purification in the David Lab

Robert pours fractions during purification of his crude compound using flash column chromatography.

Enzyme assay using radiolabeled DNA

Liz is preparing to image her gel, as part of an enzymatic activity assay which utilizes radiolabeled DNA.

Undergraduate Research - Kinetics assay preparation

Undergraduate researcher Sunbal is preparing reagents and dilutions to set up for a kinetics assay with her graduate student mentor Nicole.

Kori prepares a fluorescence-based enzyme activity assay

Kori is pipetting the necessary reagents into a well plate for her fluorescence-based enzyme activity assay.

Checking for colonies

Cindy inspects for colonies of transformed bacteria strain E. coli.

Undergraduate Research - Synthesis of Modified Nucleosides

Undergraduate Researcher Ellen Chu runs flash column chromatography on a modified nucleoside.

Graduate Student Spotlight

Introducing the David Lab Graduate Student Spotlight! Check out our conversation with Nicole as she discusses her journey as a Ph.D. student working in the David Lab.

David Lab Members

David Lab Group Picture – Feb. 2018

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Keywords: #DavidLab #TheDavidLab #UCDavis #DNA #DNARepair #Muty #Mutyh #8OG #enzymes #ModifiedOligonucleotides #ModifiedNucleosides #OrganicSynthesis #Synthesis #BaseExcisionRepair #BER #NEIL #ChemicalBiology #Chemistry #SheilaDavid #UCDavisChemistry #glycosylase