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Welcome to the David Lab Website!



The David Lab at UC Davis utilizes numerous tools of chemical biology to explore the complex mechanistic details of DNA repair enzymes. DNA repair proteins such as MutY and NEIL, among the targets of research of the David Lab, help catalyze necessary repair of oxidative DNA damage, and are critical to maintaining genomic integrity in organisms living in the oxygen-rich environment of Earth. The David Lab is headed by Dr. Sheila S. David, who has led at the forefront of DNA repair research for over 25 years. The David Lab continues to push forward the world’s current understanding of DNA repair enzymes by leaning on its unique expertise with chemical synthesis and enzyme kinetics experiments.



Featured Articles:



Featured Photos:



ACS Chemical Biology LiveSlides Presentation: 

Structure–Activity Relationships Reveal Key Features of 8-Oxoguanine: A Mismatch Detection by the MutY Glycosylase

Listen in while Chandrima Majumdar explains this recent work from the David Lab, which was selected as an ACS Editor’s Choice article.



For the latest David Lab updates, check out the News section.

Click on Research for an overview of The David Lab’s research.

A thorough list of publications is available in the Publications section. t the News section.

Click on Research for an overview of The David Lab’s research.

A thorough list of publications is available in the Publications section.



Research in the David Lab:



Graduate Student Spotlight

Introducing the David Lab Graduate Student Spotlight! Check out our conversation with Nicole as she discusses her journey as a Ph.D. student working in the David Lab.

 

 



David Lab Members

David Lab Group Picture – Feb. 2018



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Keywords: #DavidLab #TheDavidLab #UCDavis #DNA #DNARepair #Muty #Mutyh #8OG #enzymes #ModifiedOligonucleotides #ModifiedNucleosides #OrganicSynthesis #Synthesis #BaseExcisionRepair #BER #NEIL #ChemicalBiology #Chemistry #SheilaDavid #UCDavisChemistry #glycosylase



 

Contact:

Dr. Sheila S. David
ssdavid@ucdavis.edu
(530)-752-4280

Department of Chemistry
One Shields Ave.
Davis, CA 95616

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