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Congratulations to Dr. Merve Demir!
A big belated congratulations to Dr. Merve Demir on filing her dissertation! Her research has helped further our understanding of the mechanisms and structures involved in MutY’s identification of the OG lesion and the excision of the misincorporated adenine. We wish her the best of luck as she continues her research adventures as a Postdoctoral Associate at the Conrad Prebys Center at SBP!
Congratulations to Professor Sheila David on Receiving the 2022 Education Award
Congratulations to Professor Sheila David on Receiving the 2022 Education Award
10/12/2022
Professor David receives the 2022 Education Award by the Environmental Mutagenesis and Genomics Society (EMGS). The EMGS recognizes her contributions to educating students and young investigators in environmental mutagenesis and genomics. Professor David continues to dedicate her time to mentor and teach both undergraduate and graduate students in the field.
Once again, congratulations to Professor David!
Congratulations to our students!!
Many congratulations to our graduate students!
Elizabeth Lotsof won the Raymon M. Keefer Fellowship which is awarded to graduate students pursing a Ph.D. in Chemistry.
Cindy Khuu won the Floyd and Mary Schwall Dissertation Year Fellowship in Medical Research which is awarded to continuing graduate students focused on medically related research.
Congratulations to our undergraduates!
Vivian Kellner won both the Maureen Belletini Undergraduate Research Fellowship which is awarded to continuing juniors or seniors and the Francesca Miller Undergraduate Summer Research Fellowship which is awarded to a junior or senior undergraduate pursing research in the biomedical or pharmaceutical science. Vivian participated in the annual R. Bryan Miller Symposium which was a requirement for the Francesca Miller Fellowship.
Madeline Bright was named the 2021 University Medalist, this highly prestigious award is given to the top graduating senior at UC Davis for their studies, contributions to community service, and aspirations to their future goals. UC Davis published a news article about Madeline that can be read here: https://www.ucdavis.edu/news/questions-drive-top-uc-davis-graduate
We are so proud of all of our students!!
Congratulations to our R. Bryan Miller Symposium 2021 Award Winners!
Congratulations to our R. Bryan Miller Symposium 2021 Award Winners!
Thank you for your dedication to excellence!
Recent Article Published: Unique H-bonding of Adenine with oxidatively damaged base 8-oxoguanosine enables specific recognition and repair by DNA glycosylase MutY.
Recent Article Published by Sheila David’s Lab: Unique Hydrogen Bonding of Adenine with the Oxidatively Damaged Base 8-Oxoguanine Enables Specific Recognition and Repair by DNA Glycosylase MutY.
Majumdar, C.; Mckibbin, P.L.; Krajewski, A.E.; Manlove, A.H.; Lee, J.K.; David, S.S.
J. Am. Soc. 2020. 142, 48, 20340–20350.
DNA repair protein MutY employs specific interactions to differentiate OG:A basepairs from canonical G:C and T:A basepairs. Prior work from our lab has focused on understanding the structural requirements of OG on lesion recognition and catalysis, and we have shown that MutY relies on the exocyclic 2-amino group of OG to identify and distinguish OG:A from other basepairs. Additionally, we’ve shown that OG binding induces conformational changes that influence A excision.
This new work uses structure-activity relationships (SARs) to identify the structural features of A that influence OG:A recognition, verification, base excision, and overall cellular repair. We correlate observed in vitro MutY activity on A analogue substrates with their experimental and calculated acidities to provide mechanistic insight into the factors influencing MutY base excision efficiency. Our results herein can be used to guide future design of MutY/MUTYH specific probes to monitor the activity, or lack thereof, of MutY/MUTYH variants. These results can also applied toward the development of MUTY/MUTYH specific inhibitors that may find utility in cancer therapeutics.
Click on the link or graphical abstract to find out more!
https://pubs.acs.org/doi/abs/10.1021/jacs.0c06767#
Congratulations to Doug Banda and coworkers!
5/31/2017
Congratulations to David Lab authors Doug, Nicole, Michael, and Katie on their recently released article, “Repair of 8-OXOG:A Mismatches by the MUTYH Glycosylase: Mechanisms, Metals and Medicine,” in Free Radical Biology and Medicine! The final version of the article is now available online.
Link to their new article here: https://authors.elsevier.com/a/1V8Lr3AkHAI6DS.
Science Daily News
- New, exhaustive study probes hidden history of horses in the American West March 30, 2023Indigenous peoples as far north as Wyoming and Idaho may have begun to care for horses by the first half of the 17th Century, according to a new study by researchers from 15 countries and multiple Native American groups.
- Astronomers witness the birth of a very distant cluster of galaxies from the early Universe March 30, 2023Astronomers have discovered a large reservoir of hot gas in the still-forming galaxy cluster around the Spiderweb galaxy -- the most distant detection of such hot gas yet. Galaxy clusters are some of the largest objects known in the Universe and this result further reveals just how early these structures begin to form.
- Deep ocean currents around Antarctica headed for collapse, study finds March 30, 2023Antarctic circulation could slow by more than 40 per cent over the next three decades, with significant implications for the oceans and the climate.
- Brightest gamma-ray burst ever observed reveals new mysteries of cosmic explosions March 28, 2023Scientists believe the gamma-ray emission, which lasted over 300 seconds, is the birth cry of a black hole, formed as the core of a massive and rapidly spinning star collapses under its own weight.
- Temperature of a rocky exoplanet measured March 27, 2023An international team of researchers has used NASA's James Webb Space Telescope to measure the temperature of the rocky exoplanet TRAPPIST-1 b. The measurement is based on the planet's thermal emission: heat energy given off in the form of infrared light detected by Webb's Mid-Infrared Instrument (MIRI). The result indicates that the planet's dayside has […]