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Recent Article Published: Unique H-bonding of Adenine with oxidatively damaged base 8-oxoguanosine enables specific recognition and repair by DNA glycosylase MutY.
Recent Article Published by Sheila David’s Lab: Unique Hydrogen Bonding of Adenine with the Oxidatively Damaged Base 8-Oxoguanine Enables Specific Recognition and Repair by DNA Glycosylase MutY. Majumdar, C.; Mckibbin, P.L.; Krajewski, A.E.; Manlove, A.H.; Lee, J.K.; David, S.S. J. Am. Soc. 2020. 142, 48, 20340–20350. DNA repair protein MutY employs specific […]
New Manuscript Published: The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair.
New Manuscript Published: The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair. A recent publication from the David, Siegel and Lim (Academia Sinica, Taiwan) labs (Nuñez et al., JACS, 2018) provides insight into the coordination sphere and critical role of a Zn2+ metal […]
Just Accepted Manuscript: Structure Activity Relationships Reveal Key Features of 8-Oxoguanine:Adenine Mismatch Detection by the MutY DNA Glycosylase
7/20/2017 The recently accepted manuscript, Structure Activity Relationships Reveal Key Features of 8-Oxoguanine:Adenine Mismatch Detection by the MutY DNA Glycosylase, was accepted for publication in ACS Chemical Biology. MutY, remarkably, is able to specifically recognize and initiate repair of target OG:A mismatches from among a vast sea of natural DNA. To help reveal molecular features of […]
Congratulations to Doug Banda and coworkers!
5/31/2017 Congratulations to David Lab authors Doug, Nicole, Michael, and Katie on their recently released article, “Repair of 8-OXOG:A Mismatches by the MUTYH Glycosylase: Mechanisms, Metals and Medicine,” in Free Radical Biology and Medicine! The final version of the article is now available online. Link to their new article here: https://authors.elsevier.com/a/1V8Lr3AkHAI6DS.
Science Daily News
- America is throwing away the minerals that could power its future September 18, 2025America already mines all the critical minerals it needs for energy, defense, and technology, but most are being wasted as mine tailings. Researchers discovered that minerals like cobalt, germanium, and rare earths are discarded in massive amounts, even though recovering just a fraction could eliminate U.S. dependence on imports.
- Scientists stunned by salt giants forming beneath the Dead Sea September 18, 2025The Dead Sea isn’t just the saltiest body of water on Earth—it’s a living laboratory for the formation of giant underground salt deposits. Researchers are unraveling how evaporation, temperature shifts, and unusual mixing patterns lead to phenomena like “salt snow,” which falls in summer as well as winter. These processes mirror what happened millions of […]
- Tiny protein pairs may hold the secret to life’s origin September 18, 2025A team from the University of Illinois has uncovered surprising evolutionary links between the genetic code and tiny protein fragments called dipeptides. By analyzing billions of dipeptide sequences across thousands of species, the researchers revealed that these molecular pairs trace the earliest steps in the origin of life.
- Doctors warn of a stealth opioid 20x more potent than fentanyl September 18, 2025Nitazenes, a powerful and largely hidden class of synthetic opioids, are quickly becoming a deadly factor in the overdose crisis. Over 20 times stronger than fentanyl, these drugs often go undetected on routine drug tests, making overdoses harder to diagnose and reverse. Cases from Tennessee reveal a disturbing pattern of fatalities, with nitazenes frequently mixed […]
- The hidden group that loses COVID protection fast September 18, 2025Why do some people stay protected after vaccination while others quickly lose immunity? Researchers in Japan tracked over 2,500 people for 18 months and found four distinct immune response patterns. The so-called “rapid-decliners” looked strong at first but lost antibodies quickly, leaving them more vulnerable to infection.