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Welcome to the David Lab! We use chemical approaches to investigate the fascinating area of DNA repair.  Damage to DNA can result in deleterious outcomes, such as cancer and aging; fortunately, most DNA damage is repaired by DNA repair enzymes.  Our laboratory focuses on the repair of damaged DNA bases which is mediated by the process of base excision repair.  The key enzymes in this pathway are the damage-specific DNA glycosylases that search through the vast amount of normal DNA to find subtle potentially mutagenic base modifications.  Our goals are to understand the molecular details associated with the recognition and repair of DNA damage, and how these features impact mutagenesis and carcinogenesis.  As chemical biologists interested in DNA repair, we use a variety of approaches, including enzymology, synthesis of modified substrates, spectroscopy, and cell biology.  Importantly, putting these approaches together in unique ways allows connections to be made between the molecular insight derived from our in vitro studies, and how these features impact repair in cells.  Ultimately this will reveal the critical features of the DNA repair process that prevents deleterious mutations leading to cancer, and how these processes may be manipulated for beneficial therapeutic purposes.

News from the David Lab
September 2014
The David lab welcomes Dr. Jonathan Ashby as a new postdoc! Good luck to Jongchan Yeo with starting his Postdoc. We will miss you!

June 2014
Congratulations to Dr. Ryan Woods on his new job, Dr. JongChan Yeo on his new Postdoc and Dr. Patrick Rogers on his internship!

May 2014
All three of the second years have made it through their QEs! Congratulations to Nicole Chaffee, Doug Banda, and Brittany Anderson on overcoming this huge milestone!

December 2013
Congratulations to Dr. Alan Raetz for completing his Ph.D!

Welcome Dr. Xiaoyan Ma to the David lab as our latest postdoc!