Welcome to the David Lab!
We use chemical approaches to investigate the
fascinating area of DNA repair. Damage to DNA can result in
deleterious outcomes, such as cancer and aging;
fortunately, most DNA damage is repaired by DNA
repair enzymes. Our
laboratory focuses on the repair of damaged DNA
bases which is mediated by the process of base
excision repair. The
key enzymes in this pathway are the damage-specific
DNA glycosylases that search through the vast amount
of normal DNA to find subtle potentially mutagenic
base modifications. Our goals are to understand
the molecular details associated with the
recognition and repair of DNA damage, and how these
features impact mutagenesis and
chemical biologists interested in DNA repair, we use
a variety of approaches, including enzymology,
synthesis of modified substrates, spectroscopy, and
cell biology. Importantly,
putting these approaches together in unique ways
allows connections to be made between the molecular
insight derived from our in vitro studies, and how
these features impact repair in cells. Ultimately
this will reveal the critical features of the DNA
repair process that prevents deleterious mutations
leading to cancer, and how these processes may be
manipulated for beneficial therapeutic purposes.
| News from
the David Lab
Congratulations to Dr. Ryan Woods on his new job, Dr.
JongChan Yeo on his new Postdoc and Dr. Patrick Rogers
on getting through graduation!
All three of the second years have made it through
their QEs! Congratulations to Nicole Chaffee, Doug
Banda, and Brittany Anderson on overcoming this huge
Congratulations to Dr. Alan Raetz for
completing his Ph.D!
Welcome Dr. Xiaoyan Ma to the David lab as our latest