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Elizabeth Rose Lotsof

Elizabeth Rose Lotsof

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Education: 

B.A. Chemistry: Biochemistry Concentration, Cum Laude

Minors in Educational studies and Anthropology, Washington University in St. Louis

From: Chicago, Illinois

Joined the David Lab: January 2017

Outside of lab: I enjoy kickboxing, skiing, music concerts, dancing and baking.

Research in David Lab:

The NEIL family of DNA glycosylases are critical enzymes to maintaining the integrity of the genome. They initiate the base excision repair (BER) pathway by cleaving the N-glycosidic bond between the oxidatively damaged base and the sugar. NEIL1 and NEIL3 have a unique ability to excise a wide variety of substrates and remove lesions from alternative DNA contexts. Because of these abilities, I am currently evaluating the ability of NEIL1 and NEIL3 to excise oxidative base damage from G-quadruplex structures. G-quadruplexes DNA structures that occur in sequences that contain three or four adjacent guanines, which can Hoogsteen hydrogen-bond together to from a G-quartet. These G-quartets will stack together with a central K+ or Na+ ion to stabilize the structure in a variety of conformations. What makes the G-quadruples so notable is their location in the promoter sequences of many oncogenes and BER glycosylases, NEIL1 and NEIL3, and they have been implicated in down- or up-regulating gene transcription. Additionally, due to their high G content, G-quadruplexes are prime spots for oxidative damage necessitating repair by the BER pathway. NEIL’s ability to cleave from such structures suggest a dynamic relationship between DNA repair and gene regulation.

Previous Research Experience:

I previously worked as a Research Coordinator for the NorthShore University Health System’s Division of Urogynecology, where I studied the factors that impact patient persistence with urological medication and the relationship between different Urogynecological surgeries and their post-operative results, in addition to managing ongoing clinical trials.  In addition to my research work, I am passionate about science communication and accessibility and helping those with rare genetic diseases. I hope to one day have a career with a biotechnology company focused on therapeutics for individuals with rare genetic diseases.

RSS Science Daily News

  • Turning carbon emissions into methane fuel November 21, 2024
    Chemists have developed a novel way to capture and convert carbon dioxide into methane, suggesting that future gas emissions could be converted into an alternative fuel using electricity from renewable sources.
  • Thanksgiving special: Dinosaur drumsticks and the story of the turkey trot November 20, 2024
    Wings may be the obvious choice when studying the connection between dinosaurs and birds, but a pair of paleontologists prefer drumsticks. That part of the leg, they say, is where fibular reduction among some dinosaurs tens of millions of years ago helped make it possible for peacocks to strut, penguins to waddle, and turkeys to […]
  • Superior photosynthesis abilities of some plants could hold key to climate-resilient crops November 20, 2024
    Scientists discovered a stretch of DNA in both C3 plants, like wheat and soybeans, and C4 plants, like corn and sorghum, that is responsible for optimizing C4 plant photosynthesis and making them better at withstanding heat and drought. The findings are insightful in understanding how some plants evolved to be more efficient, and may now […]
  • Healthy women have cells that resemble breast cancer November 20, 2024
    A new study finds that, in healthy women, some breast cells that otherwise appear normal may contain chromosome abnormalities typically associated with invasive breast cancer. The findings question conventional thinking on the genetic origins of breast cancer, which could influence early cancer detection methods. The study discovered that at least 3% of normal cells from […]
  • Astronomers discover first pairs of white dwarf and main sequence stars in clusters, shining new light on stellar evolution November 19, 2024
    Astronomers have discovered the first pairs of white dwarf and main sequence stars -- 'dead' remnants and 'living' stars -- in young star clusters. This breakthrough offers new insights on an extreme phase of stellar evolution, and one of the biggest mysteries in astrophysics.

Contact:

Dr. Sheila S. David
ssdavid@ucdavis.edu
(530)-752-4280

Department of Chemistry
One Shields Ave.
Davis, CA 95616