Home » Chandrima Majumdar

Chandrima Majumdar

Chandrima Majumdar

LinkedIn

Education:

B.S. Chemistry (Hons.) St. Stephen’s College, Delhi, India

M.S. Chemistry University of Hyderabad, Hyderabad, India

From: Bangalore, India

Joined the David Lab: January 2015

Outside lab: I enjoy cooking, traveling, reading and creative

activities like painting and craftwork.

 

Research in David Lab:

My thesis project in the David lab is focused on understanding how MutY identifies OG:A mispairs within DNA and distinguishes it from an undamaged T:A base pair. This is a challenging task for the enzyme since OG:A mispairs are innocuous and resemble a normal T:A base-pair so closely, that they do not distort the DNA helix at all. However, the failure of MutY to locate all the OG:A mispairs and initiate their repair can be disastrous as their replication forms normal, undamaged, but mutated T:A base-pairs that can no longer be corrected by the DNA repair machinery. As a result, MutY has the unique and crucial role of weeding out and initiating the repair of the OG:A mispair, while being able to distinguish it from the vast excess of undamaged DNA. I use structural analogs of OG and A to study the process by which MutY recognizes these mispairs. The analogs have functional groups with modified steric, hydrogen bonding and electronic properties that help us understand the role of these features in MutY’s ability to identify the lesion and excise the A.

 

Links to Papers from David Lab:

Majumdar, C.; Nuñez, N. N.; Raetz, A. G.; Khuu, C.; David, S. S., Chapter Three – Cellular Assays for Studying the Fe–S Cluster Containing Base Excision Repair Glycosylase MUTYH and Homologs. In Methods in Enzymology, David, S. S., Ed. Academic Press: 2018; Vol. 599, pp 69-99.

Nuñez, N. N.; Majumdar, C.; Lay, K. T.; David, S. S., Fe–S Clusters and MutY Base Excision Repair Glycosylases: Purification, Kinetics, and DNA Affinity Measurements. In Methods in Enzymology, Academic Press: 2018.

Manlove, A. H.; McKibbin, P. L.; Doyle, E. L.; Majumdar, C.; Hamm, M. L.; David, S. S., Structure–Activity Relationships Reveal Key Features of 8-Oxoguanine: A Mismatch Detection by the MutY Glycosylase. ACS Chemical Biology 2017, 12 (9), 2335-2344.

 

Previous Research Experience:

My previous research experience includes working as a summer researcher in Dr. Debashis Chakraborty’s lab at the Indian Institute of Technology Madras on developing a mild and chemoselective method for oxidizing aldehydes. I also worked on a summer project in Dr. Suvarn Kulkarni’s lab at the Indian Institute of Technology Bombay on the synthesis of carbohydrate building blocks as starting materials. While pursuing my M.Sc. at the University of Hyderabad , I did research with Dr. Rengarajan Balamurugan on the synthesis of substituted pyridines from alkenes using gold and silver catalysts.

http://onlinelibrary.wiley.com/doi/10.1002/aoc.1787/full

RSS Science Daily News

  • Down goes antimatter! Gravity's effect on matter's elusive twin is revealed September 27, 2023
    For the first time, in a unique laboratory experiment at CERN, researchers have observed individual atoms of antihydrogen fall under the effects of gravity. In confirming antimatter and regular matter are gravitationally attracted, the finding rules out gravitational repulsion as the reason why antimatter is largely missing from the observable universe.
  • Decreasing biodiversity may promote spread of viruses September 27, 2023
    How are environmental changes, loss of biodiversity, and the spread of pathogens connected? The answer is a puzzle. Researchers have now described one piece of that puzzle, showing that the destruction of tropical rainforests harms the diversity of mosquito species. At the same time, more resilient species of mosquitoes become more prevalent -- which also […]
  • Study sheds new light on strange lava worlds September 27, 2023
    In a new study, scientists have shown that sweeping molten oceans have a large influence on the observed properties of hot rocky Super-Earths, such as their size and evolutionary path.
  • New insights into the atmosphere and star of an exoplanet September 25, 2023
    A new study of the intriguing TRAPPIST-1 exoplanetary system has demonstrated the complex interaction between the activity of the system's star and its planetary features.
  • Did life exist on Mars? Other planets? With AI's help, we may know soon September 25, 2023
    Scientists have discovered a simple and reliable test for signs of past or present life on other planets -- 'the holy grail of astrobiology.' Researchers report that, with 90% accuracy, their artificial intelligence-based method distinguished modern and ancient biological samples from those of abiotic origin.

Contact:

Dr. Sheila S. David
ssdavid@ucdavis.edu
(530)-752-4280

Department of Chemistry
One Shields Ave.
Davis, CA 95616