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Elizabeth Rose Lotsof

Elizabeth Rose Lotsof

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Education: 

B.A. Chemistry: Biochemistry Concentration, Cum Laude

Minors in Educational studies and Anthropology, Washington University in St. Louis

From: Chicago, Illinois

Joined the David Lab: January 2017

Outside of lab: I enjoy kickboxing, skiing, music concerts, dancing and baking.

Research in David Lab:

The NEIL family of DNA glycosylases are critical enzymes to maintaining the integrity of the genome. They initiate the base excision repair (BER) pathway by cleaving the N-glycosidic bond between the oxidatively damaged base and the sugar. NEIL1 and NEIL3 have a unique ability to excise a wide variety of substrates and remove lesions from alternative DNA contexts. Because of these abilities, I am currently evaluating the ability of NEIL1 and NEIL3 to excise oxidative base damage from G-quadruplex structures. G-quadruplexes DNA structures that occur in sequences that contain three or four adjacent guanines, which can Hoogsteen hydrogen-bond together to from a G-quartet. These G-quartets will stack together with a central K+ or Na+ ion to stabilize the structure in a variety of conformations. What makes the G-quadruples so notable is their location in the promoter sequences of many oncogenes and BER glycosylases, NEIL1 and NEIL3, and they have been implicated in down- or up-regulating gene transcription. Additionally, due to their high G content, G-quadruplexes are prime spots for oxidative damage necessitating repair by the BER pathway. NEIL’s ability to cleave from such structures suggest a dynamic relationship between DNA repair and gene regulation.

Previous Research Experience:

I previously worked as a Research Coordinator for the NorthShore University Health System’s Division of Urogynecology, where I studied the factors that impact patient persistence with urological medication and the relationship between different Urogynecological surgeries and their post-operative results, in addition to managing ongoing clinical trials.  In addition to my research work, I am passionate about science communication and accessibility and helping those with rare genetic diseases. I hope to one day have a career with a biotechnology company focused on therapeutics for individuals with rare genetic diseases.

RSS Science Daily News

  • New Orleans is sinking—and so are its $15 billion flood defenses June 29, 2025
    Parts of New Orleans are sinking at alarming rates — including some of the very floodwalls built to protect it. A new satellite-based study finds that some areas are losing nearly two inches of elevation per year, threatening the effectiveness of the city's storm defenses.
  • Record-breaking 10-billion-year radio halo just rewrote the universe’s origin story June 28, 2025
    A newly discovered radio halo, 10 billion light-years away, reveals that galaxy clusters in the early universe were already steeped in high-energy particles. The finding hints at ancient black hole activity or cosmic particle collisions fueling this energy.
  • A mysterious mineral in asteroid Ryugu may rewrite planetary history June 28, 2025
    A surprising discovery from a tiny grain of asteroid Ryugu has rocked scientists' understanding of how our Solar System evolved. Researchers found djerfisherite—a mineral typically born in scorching, chemically reduced conditions and never before seen in Ryugu-like meteorites—inside a sample returned by Japan’s Hayabusa2 mission. Its presence suggests either Ryugu once experienced unexpectedly high temperatures […]
  • A giant pulse beneath Africa could split the continent — and form an ocean June 27, 2025
    Beneath the Afar region in Ethiopia, scientists have discovered pulsing waves of molten rock rising from deep within the Earth — a geological heartbeat that could eventually split Africa in two. These rhythmic surges of mantle material are helping to stretch and thin the continent’s crust, setting the stage for a new ocean to form […]
  • World’s largest camera just snapped the Universe in 3,200 megapixels June 27, 2025
    The LSST camera at the Vera C. Rubin Observatory has released its jaw-dropping first images, each capturing 45 times the area of the full moon in one shot. Over the next ten years, this cosmic giant will scan the southern sky in ultra-HD, helping scientists uncover everything from asteroids to the secrets of dark energy.

Contact:

Dr. Sheila S. David
ssdavid@ucdavis.edu
(530)-752-4280

Department of Chemistry
One Shields Ave.
Davis, CA 95616