Home » Home?

Home?

Welcome to the David Lab Website!



The David Lab at UC Davis utilizes numerous tools of chemical biology to explore the complex mechanistic details of DNA repair enzymes. DNA repair proteins such as MutY and NEIL, among the targets of research of the David Lab, help catalyze necessary repair of oxidative DNA damage, and are critical to maintaining genomic integrity in organisms living in the oxygen-rich environment of Earth. The David Lab is headed by Dr. Sheila S. David, who has led at the forefront of DNA repair research for the last 30 years. The David Lab continues to push forward the world’s current understanding of DNA repair enzymes by leveraging our unique expertise in DNA repair enzymology while venturing into new areas and collaborating with scientists around the world.



Featured Article: 

Structural snapshots of base excision by the cancer-associated variant MutY N146S reveal a retaining mechanism

Nucleic Acids Research

“We captured structural snapshots of N146S Geobacillus stearothermophilus MutY bound to DNA containing a substrate, a transition state analog and enzyme-catalyzed abasic site products to provide insight into the base excision mechanism of MutY and the role of Asn.”

Click on the link to read more!

https://doi.org/10.1093/nar/gkac1246

 

 

Authors:
Merve Demir, L Peyton Russelburg, Wen-Jen Lin, Carlos H Trasviña-Arenas, Beili Huang, Philip K Yuen, Martin P Horvath*, and Sheila S David*

Nucleic Acids Res. Jan. 12 2023, gkac1246.



Recent Articles:

 



Featured Photos:

Savannah completed her 3rd Year Seminar on Zoom – Congrats Savannah!

 



ACS Chemical Biology LiveSlides Presentation: 

Structure–Activity Relationships Reveal Key Features of 8-Oxoguanine: A Mismatch Detection by the MutY Glycosylase

Listen in while Chandrima Majumdar explains this recent work from the David Lab, which was selected as an ACS Editor’s Choice article.



For the latest David Lab updates, check out the News section.

Click on Research for an overview of The David Lab’s research.

A thorough list of publications is available in the Publications section.



Graduate Student Spotlight

In our second installment of David Lab Graduate Student Spotlight, you will meet Elizabeth Lotsof, a Graduate Student in Sheila David’s lab at UC Davis in the Department of Chemistry seeking to earn her Ph.D. in Chemistry. Liz focuses on DNA repair enzyme NEIL in her research. Watch now to catch her commentary on graduate school and the David Lab!


Introducing the David Lab Graduate Student Spotlight! Check out our conversation with Nicole as she discusses her journey as a Ph.D. student working in the David Lab.



Undergraduate Student Spotlight

Meet UC Davis Undergraduate Researcher Madeline Bright in our lab’s new Undergraduate Student Spotlight Video!



David Lab FYI Video

How to efficiently pour column fractions: Run a column <60 min.

Doing this will greatly increase your already-existing love of columns. And your productivity.

Get the most out of your flash column. It’s not called slow column chromatography.

Use this information at your own risk. This video is intended for graduate / professional level researchers. Be sure to follow your lab’s safety protocols.

Video by Robert Van Ostrand.

David Lab YouTube Trailer – June 2020

Subscribe to our YouTube Channel!



A tribute to Jongchan Yeo, you are dearly missed.

Jongchan Yeo was a cherished member of the lab. He received his PhD in Chemistry in 2014 and went on to attend UC Berkeley for his post-doctoral training. He is pictured with Sheila David in his bright pink shirt that he wore while at the library for his students to find him (left) and presenting his research poster at EMGS (right). Thank you for all of your hard work.

 

His work from our lab has been published in Biochemistry.

Check it out here!



David Lab Members

The David Lab – April 2019


Follow us on Instagram!



Keywords: #DavidLab #TheDavidLab #UCDavis #DNA #DNARepair #Muty #Mutyh #8OG #enzymes #ModifiedOligonucleotides #ModifiedNucleosides #OrganicSynthesis #Synthesis #BaseExcisionRepair #BER #NEIL #ChemicalBiology #Chemistry #SheilaDavid #UCDavisChemistry #glycosylase #DNARepairUCDavis


RSS Science Daily News

  • Matching your workouts to your personality could make exercising more enjoyable and give you better results July 9, 2025
    Less than a quarter of us hit WHO activity targets, but a new UCL study suggests the trick may be matching workouts to our personalities: extroverts thrive in high-energy group sports, neurotics prefer private bursts with breaks, and everyone sees stress levels drop when they find exercise they enjoy.
  • Scientists just recreated a 1938 experiment that could rewrite fusion history July 9, 2025
    A groundbreaking collaboration between Los Alamos scientists and Duke University has resurrected a nearly forgotten 1938 experiment that may have quietly sparked the age of fusion energy. Arthur Ruhlig, a little-known physicist, first observed signs of deuterium-tritium (DT) fusion nearly a decade before its significance became clear in nuclear science. The modern team not only […]
  • Astronomers Catch Planets in the Act of Being Born July 9, 2025
    Astronomers have spotted centimeter-sized “pebbles” swirling around two infant stars 450 light-years away, revealing the raw ingredients of planets already stretching to Neptune-like orbits. Using the UK’s e-MERLIN radio array, the PEBBLeS project found these rocky seeds in unprecedented detail, bridging the elusive gap between dusty discs and fully-formed worlds. The discovery hints that systems […]
  • Ice in a million-degree Fermi bubble reveals the Milky Way’s recent eruption July 9, 2025
    Astronomers using the Green Bank Telescope spotted surprisingly cold, dense hydrogen clouds embedded inside the Milky Way’s vast, super-hot Fermi bubbles—structures thought to be created by a recent, violent outburst from the galaxy’s core. Because such chilled gas should evaporate quickly in million-degree surroundings, its survival hints that the bubbles are only about a million […]
  • Hidden DNA-sized crystals in cosmic ice could rewrite water—and life itself July 9, 2025
    Scientists from UCL and the University of Cambridge have revealed that "space ice"—long thought to be completely disordered—is actually sprinkled with tiny crystals, changing our fundamental understanding of ice in the cosmos. These micro-crystals, just nanometers wide, were identified through simulations and lab experiments, revealing that even the most common ice in space retains a […]

Contact:

Dr. Sheila S. David
ssdavid@ucdavis.edu
(530)-752-4280

Department of Chemistry
One Shields Ave.
Davis, CA 95616