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Jonathan Lin

Jonathan Lin

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Education:

B.S. Chemical biology, B.A. Music, UC Berkeley 2017

From:  San Jose, CA

Joined the David Lab: January 2018

Outside of lab: Music and the ergometer

 

 

Research in the David Lab

Oxidative damage to DNA can cause genetic mutations that lead to cancer. A lack of activity by DNA repair enzymes such as glycosylases deters the removal of these damaged DNA base pairs. Using synthetic methods, I develop nucleoside/nucleotide analogues that will serve as inhibitors of various DNA glycosylases. Doing so will allow us to “trap” these enzymes in action, in vitro and potentially in vivo, for structural and enzymatic studies. In addition, these analogues may be used to help develop pharmaceuticals to fight cancer.

Previous Research Experience:

As a visiting researcher in Dr. Ken Wong’s lab at the National Cheng-Kung University Medical School (Tainan, Taiwan), I sought after a non-invasive method to detect the onset of squamous cell carcinoma in dystrophic epidermolysis bullosa patients through analysis of patients’ wound fluids.

 

 

RSS Science Daily News

  • Mysteries of icy ocean worlds December 21, 2024
    A study introduces a novel thermodynamic concept called the 'centotectic' and investigates the stability of liquids in extreme conditions -- critical information for determining the habitability of icy moons like Europa.
  • Can the heart heal itself? New study says it can December 21, 2024
    Physician-scientists found that a subset of artificial heart patients can regenerate heart muscle, which may open the door to new ways to treat and perhaps someday cure heart failure.
  • Water and gruel -- not bread: Discovering the diet of early Neolithic farmers in Scandinavia December 20, 2024
    At a Neolithic settlement on the Danish island Funen dating back 5,500 years, archaeologists have discovered both grinding stones and grains from early cereals. However, new research reveals that the inhabitants did not use the stones to grind the cereal grains. Instead of making bread, they likely prepared porridge or gruel from the grains.
  • Dark energy 'doesn't exist' so can't be pushing 'lumpy' Universe apart December 20, 2024
    One of the biggest mysteries in science -- dark energy -- doesn't actually exist, according to researchers looking to solve the riddle of how the Universe is expanding. For the past 100 years, physicists have generally assumed that the cosmos is growing equally in all directions. They employed the concept of dark energy as a […]
  • Growing safer spuds: Removing toxins from potatoes December 20, 2024
    Scientists have discovered a way to remove toxic compounds from potatoes and tomatoes, making them safer to eat and easier to store. The breakthrough could cut food waste and enhance crop farming in extreme environments, like outer space.

Contact:

Dr. Sheila S. David
ssdavid@ucdavis.edu
(530)-752-4280

Department of Chemistry
One Shields Ave.
Davis, CA 95616