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Jonathan Lin

Jonathan Lin

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Education:

B.S. Chemical biology, B.A. Music, UC Berkeley 2017

From:  San Jose, CA

Joined the David Lab: January 2018

Outside of lab: Music and the ergometer

 

 

Research in the David Lab

Oxidative damage to DNA can cause genetic mutations that lead to cancer. A lack of activity by DNA repair enzymes such as glycosylases deters the removal of these damaged DNA base pairs. Using synthetic methods, I develop nucleoside/nucleotide analogues that will serve as inhibitors of various DNA glycosylases. Doing so will allow us to “trap” these enzymes in action, in vitro and potentially in vivo, for structural and enzymatic studies. In addition, these analogues may be used to help develop pharmaceuticals to fight cancer.

Previous Research Experience:

As a visiting researcher in Dr. Ken Wong’s lab at the National Cheng-Kung University Medical School (Tainan, Taiwan), I sought after a non-invasive method to detect the onset of squamous cell carcinoma in dystrophic epidermolysis bullosa patients through analysis of patients’ wound fluids.

 

 

RSS Science Daily News

  • Galactic mystery: Why massive stars struggle to form in the Milky Way's center June 15, 2025
    At the heart of our galaxy lies a cosmic puzzle: although the Galactic Center is packed with star-making material, massive stars form there surprisingly slowly. Using NASA's retired SOFIA observatory, scientists captured rare high-resolution infrared views that revealed dozens of new stars being born, but not in the numbers or sizes one might expect.
  • Tiny wasp’s shocking reproductive trick may transform global agriculture June 15, 2025
    Aphid-hunting wasps can reproduce with or without sex, challenging previous assumptions. This unique flexibility could boost sustainable pest control if its hidden drawbacks can be managed.
  • Impossible signal from deep beneath Antarctic ice baffles physicists June 14, 2025
    A cosmic particle detector in Antarctica has emitted a series of bizarre signals that defy the current understanding of particle physics, according to an international research group that includes scientists from Penn State. The unusual radio pulses were detected by the Antarctic Impulsive Transient Antenna (ANITA) experiment, a range of instruments flown on balloons high […]
  • Koalas on the brink: Precision DNA test offers a lifeline to Australia’s icons June 14, 2025
    A University of Queensland-led project has developed a tool to standardise genetic testing of koala populations, providing a significant boost to conservation and recovery efforts.
  • AI Reveals Milky Way’s Black Hole Spins Near Top Speed June 14, 2025
    AI has helped astronomers crack open some of the universe s best-kept secrets by analyzing massive datasets about black holes. Using over 12 million simulations powered by high-throughput computing, scientists discovered that the Milky Way's central black hole is spinning at nearly maximum speed. Not only did this redefine theories about black hole behavior, but […]

Contact:

Dr. Sheila S. David
ssdavid@ucdavis.edu
(530)-752-4280

Department of Chemistry
One Shields Ave.
Davis, CA 95616