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Jonathan Lin

Jonathan Lin



B.S. Chemical biology, B.A. Music, UC Berkeley 2017

From:  San Jose, CA

Joined the David Lab: January 2018

Outside of lab: Music and the ergometer



Research in the David Lab

Oxidative damage to DNA can cause genetic mutations that lead to cancer. A lack of activity by DNA repair enzymes such as glycosylases deters the removal of these damaged DNA base pairs. Using synthetic methods, I develop nucleoside/nucleotide analogues that will serve as inhibitors of various DNA glycosylases. Doing so will allow us to “trap” these enzymes in action, in vitro and potentially in vivo, for structural and enzymatic studies. In addition, these analogues may be used to help develop pharmaceuticals to fight cancer.

Previous Research Experience:

As a visiting researcher in Dr. Ken Wong’s lab at the National Cheng-Kung University Medical School (Tainan, Taiwan), I sought after a non-invasive method to detect the onset of squamous cell carcinoma in dystrophic epidermolysis bullosa patients through analysis of patients’ wound fluids.



RSS Science Daily News

  • Down goes antimatter! Gravity's effect on matter's elusive twin is revealed September 27, 2023
    For the first time, in a unique laboratory experiment at CERN, researchers have observed individual atoms of antihydrogen fall under the effects of gravity. In confirming antimatter and regular matter are gravitationally attracted, the finding rules out gravitational repulsion as the reason why antimatter is largely missing from the observable universe.
  • Decreasing biodiversity may promote spread of viruses September 27, 2023
    How are environmental changes, loss of biodiversity, and the spread of pathogens connected? The answer is a puzzle. Researchers have now described one piece of that puzzle, showing that the destruction of tropical rainforests harms the diversity of mosquito species. At the same time, more resilient species of mosquitoes become more prevalent -- which also […]
  • Study sheds new light on strange lava worlds September 27, 2023
    In a new study, scientists have shown that sweeping molten oceans have a large influence on the observed properties of hot rocky Super-Earths, such as their size and evolutionary path.
  • New insights into the atmosphere and star of an exoplanet September 25, 2023
    A new study of the intriguing TRAPPIST-1 exoplanetary system has demonstrated the complex interaction between the activity of the system's star and its planetary features.
  • Did life exist on Mars? Other planets? With AI's help, we may know soon September 25, 2023
    Scientists have discovered a simple and reliable test for signs of past or present life on other planets -- 'the holy grail of astrobiology.' Researchers report that, with 90% accuracy, their artificial intelligence-based method distinguished modern and ancient biological samples from those of abiotic origin.


Dr. Sheila S. David

Department of Chemistry
One Shields Ave.
Davis, CA 95616