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Joshua Bumgarner

Joshua Bumgarner

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Education:

B.A. in Chemistry from Willamette University, Salem OR, 2017

From: Walla Walla WA

Joined David Lab: April 2018

Outside of lab: I like to go on hikes or spend time with my big goofy labradoodle. I’m also a big foodie who loves to try new restaurants and drinks

Research in David Lab:

BER glycosylases are usually highly specific in the type of damage they repair, and when they repair it. The NEIL family of glycosylases are unusual in their ability to work on a multitude of different DNA lesions, and can often do so in DNA contexts outside of canonical B-DNA. I work to understand what dictates when a NEIL enzyme repairs a lesion, and what influences when it when it does not. I have used a variety of different lesions to develop structure activity relationships between specific bases to better learn what structures of the base are required for recognition and repair, what which impair NEIL activity. In addition, most enzymatic assays are performed in dilute buffer systems, however this is not necessarily the case in a cell. The impact of the crowded environment of a cell, known as macromolecular crowding, can significantly impact enzymatic activity. I have been working to incorporate this into our enzyme assays and understand how it changes our understanding of the enzymes behavior between a test tube and the cellular environment.

Previous Research Experience:

I previously studied macromolecular crowding under Dr. Todd Silverstein at Willamette university, working to understand the influence of crowding agents on the pH profile of alcohol dehydrogenase, and how it altered the construction and pKa’s of the active site. I have also worked at the Hawaii Institute of Marine Biology studying the ability of coral to acclimate to increasing water temperatures over the past 40 years, and the inventible climb in ocean temperatures in the years to come.

RSS Science Daily News

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    Sea otters are one of the few animals that use tools to access their food, and a new study has found that individual sea otters that use tools -- most of whom are female -- are able to eat larger prey and reduce tooth damage when their preferred prey becomes depleted.
  • How did sabre-toothed tigers acquire their long upper canine teeth? May 16, 2024
    In a groundbreaking study an international team of scientists has investigated the evolutionary patterns behind the development of sabre teeth, with some unexpected results along the way.
  • Why do we overindulge? May 16, 2024
    If you tend to do other things or get distracted while eating dinner, you may be running the risk of over-consuming everyday pleasures later, possibly because the distraction caused you to enjoy yourself less, according to new research.
  • When saying 'please' is more strategic than magic May 16, 2024
    By kindergarten age, most children have been taught that 'please' is a magic word. 'Please' is an expression of politeness that shows courtesy and respect, turning a potential demand into a request that will -- poof! -- magically be granted. But a new study on the ways people make requests of one another suggests that […]
  • Jet-propelled sea creatures could improve ocean robotics May 16, 2024
    Scientists have discovered that colonies of gelatinous sea animals swim through the ocean in giant corkscrew shapes using coordinated jet propulsion, an unusual kind of locomotion that could inspire new designs for efficient underwater vehicles.

Contact:

Dr. Sheila S. David
ssdavid@ucdavis.edu
(530)-752-4280

Department of Chemistry
One Shields Ave.
Davis, CA 95616