Home » Kori Lay

Kori Lay

Kori Lay

LinkedIn

Education:

B.A. Chemistry and Environmental Studies, UC Santa Barbara 2014

From: Port Washington, New York

Joined the David Lab: January 2016

Outside of lab: I love doing outdoor activities like hiking, camping,

snowboarding. I also enjoy cooking and make a mean red Thai curry.

 

 

Research in David Lab:

My work in the David lab focuses on studying methylthioadenosine nucleosidase (MTAN), which is an enzyme found in bacteria. This enzyme is of interest to us because it is structurally similar to the human enzyme, methylthioadenosine phosphorylase (MTAP), which is an anticancer target. MTAN is also a potential antibiotic target due to it’s involvement in quorum sensing in bacteria. S-adenosylhomocysteine (SAH) is a substrate of MTAN and the transition state formed between MTAN and SAH has been used in the development of tight binding inhibitors of MTAN. Potent inhibitors of MTAN have been developed but their synthesis is arduous and long. Using Copper-Catalyzed Azide-Alkyne Cycloaddition (CuAAC), I have synthesized potential inhibitors of MTAN quickly and efficiently (shown below). Using an RNA-based fluorescent biosensor developed in the Hammond lab, I have designed an in vitro assay for detecting MTAN activity and inhibition that is easier and more sensitive than previous activity assays.1 Using this assay, I will be testing for inhibition of MTAN using the CuAAC synthesized inhibitors. This assay also works in vivo, so inhibitors will also be tested in E. coli.

 

Links to Papers from David Lab:

Nuñez, N. N.; Majumdar, C.; Lay, K. T.; David, S. S., Fe–S Clusters and MutY Base Excision Repair Glycosylases: Purification, Kinetics, and DNA Affinity Measurements. In Methods in Enzymology, Academic Press: 2018.

Shi, R.; Mullins, E. A.; Shen, X. X.; Lay, K. T.; Yuen, P. K.; David, S. S.; Rokas, A.; Eichman, B. F., Selective base excision repair of DNA damage by the non‐base‐flipping DNA glycosylase AlkC. The EMBO Journal 2017, e201797833.

Previous Research Experience:

As an undergraduate, I did research in Dr. Daniel Morse’s lab where I worked to produce transmission electron microscopy images of the cross section of iridocyte cells found in Tridacnid giant clams.2 My aim was to analyze the structure-function relationships of the internal Bragg-reflectors in these cells, to better understand the mechanism of their newly discovered enhancement of photosynthesis by the endosymbiotic algae living within the clam’s tissues.

  1. Su, Y.; Hickey, S. F.; Keyser, S. G. L.; Hammond, M. C., In Vitro and In Vivo Enzyme Activity Screening via RNA-Based Fluorescent Biosensors for S-Adenosyl-l-homocysteine (SAH). Journal of the American Chemical Society 2016, 138 (22), 7040-7047.
  2. Ghoshal, A.; Eck, E.; Morse, D. E., Biological analogs of RGB pixelation yield white coloration in giant clams. Optica 2016, 3 (1), 108-111.

RSS Science Daily News

  • These dogs are trained to sniff out an invasive insect—and they're shockingly good at it July 17, 2025
    Dogs trained by everyday pet owners are proving to be surprisingly powerful allies in the fight against the invasive spotted lanternfly. In a groundbreaking study, citizen scientists taught their dogs to sniff out the pests’ hard-to-spot egg masses with impressive accuracy. The initiative not only taps into the huge community of recreational scent-detection dog enthusiasts, […]
  • This 10-minute ozone hack keeps mangoes fresh for 28 days July 17, 2025
    Mango lovers and growers alike may soon rejoice: scientists at Edith Cowan University have found that a simple dip in ozonated water can drastically extend the shelf life of mangoes by up to two weeks while reducing spoilage. This technique, called aqueous ozonation, helps prevent chilling injuries that typically occur during cold storage, a long-standing […]
  • Cognitive collapse and the nuclear codes: When leaders lose control July 17, 2025
    A shocking study reveals that many leaders of nuclear-armed nations—including US presidents and Israeli prime ministers—were afflicted by serious health problems while in office, sometimes with their conditions hidden from the public. From dementia and depression to addiction and chronic diseases, these impairments may have affected their decision-making during pivotal global crises.
  • This flat chip uses twisted light to reveal hidden images July 17, 2025
    Using advanced metasurfaces, researchers can now twist light to uncover hidden images and detect molecular handedness, potentially revolutionizing data encryption, biosensing, and drug safety.
  • Why broken crystals are stronger July 17, 2025
    Crystals may seem flawless, but deep inside they contain tiny structural imperfections that dramatically influence their strength and behavior. Researchers from The University of Osaka have used the sophisticated math of differential geometry to reveal how these defects—like dislocations and disclinations—interact in elegant, unified ways. Their findings could help scientists engineer tougher, smarter materials by […]

Contact:

Dr. Sheila S. David
ssdavid@ucdavis.edu
(530)-752-4280

Department of Chemistry
One Shields Ave.
Davis, CA 95616