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Mo Hashemian

Mo Hashemian

Education: B.S. Biological Sciences, University of California, Irvine, 2019 

From: Irvine, California

Joined David Lab: January 2021

Outside of lab: working out, watching TV

Research in David Lab:

In the lab, I utilize techniques in molecular and structural biology, protein biochemistry and enzymology. These skills were cultivated and applied in the process of solving the first full-length structure of an important human base excision repair glycosylase, MUTYH. This work has enabled us to characterize many functional features of the enzyme but has raised additional questions pertaining to the coordination of a zinc ion which is missing from the structure. My current work involves characterizing the structural motif that binds zinc, as well as characterizing naturally occurring cancer variants surrounding this motif. Our structure of MUTYH has also informed a second project, involving the potential discovery of a small molecule inhibitor that binds to a C-terminal substrate recognition motif, thereby diminishing enzymatic activity.

RSS Science Daily News

  • New microscope can image, at once, the full 3D orientation and position of molecules in cells February 21, 2025
    A hybrid microscope allows scientists to simultaneously image the full 3D orientation and position of an ensemble of molecules, such as labeled proteins inside cells. The microscope combines polarized fluorescence technology, a valuable tool for measuring the orientation of molecules, with a dual-view light sheet microscope (diSPIM), which excels at imaging along the depth (axial) […]
  • How to get a robot collective to act like a smart material February 21, 2025
    Researchers are blurring the lines between robotics and materials, with a proof-of-concept material-like collective of robots with behaviors inspired by biology.
  • The brain perceives unexpected pain more strongly February 21, 2025
    Researchers used visual threat manipulation in the virtual reality environment and thermal stimulation to investigate how the brain perceives pain. They found that the brain perceives pain more strongly when the perceived pain is out of alignment with reality. In particular, pain was amplified when unexpected events occurred.
  • Brain-wide activity change visualized as geometric patterns February 21, 2025
    Researchers have applied a visualization technique to depict the brain's activity related to visual perception as geometric patterns. They visualized different shapes as the ever-changing neuronal activity in the temporal and frontal lobes of the brain during object recognition and recalling memories. This achievement promises further extraction of brain activity observed in various aspects of […]
  • Viking skulls reveal severe morbidity February 21, 2025
    Sweden's Viking Age population appears to have suffered from severe oral and maxillofacial disease, sinus and ear infections, osteoarthritis, and much more. This is shown in a study in which Viking skulls were examined using modern X-ray techniques.

Contact:

Dr. Sheila S. David
ssdavid@ucdavis.edu
(530)-752-4280

Department of Chemistry
One Shields Ave.
Davis, CA 95616