Home » Mo Hashemian

Mo Hashemian

Mo Hashemian

Education: B.S. Biological Sciences, University of California, Irvine, 2019 

From: Irvine, California

Joined David Lab: January 2021

Outside of lab: working out, watching TV

Research in David Lab:

In the lab, I utilize techniques in molecular and structural biology, protein biochemistry and enzymology. These skills were cultivated and applied in the process of solving the first full-length structure of an important human base excision repair glycosylase, MUTYH. This work has enabled us to characterize many functional features of the enzyme but has raised additional questions pertaining to the coordination of a zinc ion which is missing from the structure. My current work involves characterizing the structural motif that binds zinc, as well as characterizing naturally occurring cancer variants surrounding this motif. Our structure of MUTYH has also informed a second project, involving the potential discovery of a small molecule inhibitor that binds to a C-terminal substrate recognition motif, thereby diminishing enzymatic activity.

RSS Science Daily News

  • Mechanism found to determine which memories last March 28, 2024
    Neuroscientists have established in recent decades the idea that some of each day's experiences are converted by the brain into permanent memories during sleep the same night. Now, a new study proposes a mechanism that determines which memories are tagged as important enough to linger in the brain until sleep makes them permanent.
  • Alcohol raises heart disease risk, particularly among women March 28, 2024
    Young to middle-aged women who reported drinking eight or more alcoholic beverages per week--more than one per day, on average--were significantly more likely to develop coronary heart disease compared with those who drank less, finds a study presented at the American College of Cardiology's Annual Scientific Session. The risk was highest among both men and […]
  • Unlocking supernova stardust secrets March 28, 2024
    New research has discovered a rare dust particle trapped in an ancient extra-terrestrial meteorite that was formed by a star other than our sun.
  • Long-period oscillations control the Sun's differential rotation March 27, 2024
    The interior of the Sun does not rotate at the same rate at all latitudes. The physical origin of this differential rotation is not fully understood. It turns out, long-period solar oscillations discovered in 2021 play a crucial role in controlling the Sun's rotational pattern. The long-period oscillations are analogous to the baroclinically unstable waves […]
  • Artificial reef designed by MIT engineers could protect marine life, reduce storm damage March 27, 2024
    Engineers designed an 'architected' reef that can mimic the wave-buffering effects of natural reefs while providing pockets for marine life. The sustainable and cost-saving structure could dissipate more than 95 percent of incoming wave energy using a small fraction of the material normally needed.

Contact:

Dr. Sheila S. David
ssdavid@ucdavis.edu
(530)-752-4280

Department of Chemistry
One Shields Ave.
Davis, CA 95616