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Mo Hashemian

Mo Hashemian

Education: B.S. Biological Sciences, University of California, Irvine, 2019 

From: Irvine, California

Joined David Lab: January 2021

Outside of lab: working out, watching TV

Research in David Lab:

In the lab, I utilize techniques in molecular and structural biology, protein biochemistry and enzymology. These skills were cultivated and applied in the process of solving the first full-length structure of an important human base excision repair glycosylase, MUTYH. This work has enabled us to characterize many functional features of the enzyme but has raised additional questions pertaining to the coordination of a zinc ion which is missing from the structure. My current work involves characterizing the structural motif that binds zinc, as well as characterizing naturally occurring cancer variants surrounding this motif. Our structure of MUTYH has also informed a second project, involving the potential discovery of a small molecule inhibitor that binds to a C-terminal substrate recognition motif, thereby diminishing enzymatic activity.

RSS Science Daily News

  • Are mixed emotions real? New research says yes June 13, 2024
    Neuroscientists found that brains display distinct neural activity when experiencing emotions such as bitter-sweetness. The advance could help solve a longstanding scientific debate: whether 'mixed emotions' arise from unique activity in the brain, or if we're just flip-flopping back and forth between positive and negative feelings.
  • The rotation of Earth's inner core has slowed, new study confirms June 13, 2024
    The new study provides unambiguous evidence that the inner core began to decrease its speed around 2010, moving slower than the Earth's surface.
  • Paleontology: New fossil fish genus discovered June 13, 2024
    Paleontologists have identified a new genus of fossil goby, revealing evolutionary secrets of a lineage that stretches back millions of years.
  • 6,000 years ago, men and women had equal access to resources June 13, 2024
    Using isotope geochemistry, scientists have uncovered new information about the Barmaz necropolis in Valais (Switzerland): 14% of the people buried 6,000 years ago at this site were not locals. What's more, the study suggests that this Middle Neolithic agropastoral society -- one of the oldest known in the western part of Switzerland -- was relatively […]
  • Ancient ocean slowdown warns of future climate chaos June 13, 2024
    When it comes to the ocean's response to global warming, we're not in entirely uncharted waters. A new study shows that episodes of extreme heat in Earth's past caused the exchange of waters from the surface to the deep ocean to decline.

Contact:

Dr. Sheila S. David
ssdavid@ucdavis.edu
(530)-752-4280

Department of Chemistry
One Shields Ave.
Davis, CA 95616