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Mo Hashemian

Mo Hashemian

Education: B.S. Biological Sciences, University of California, Irvine, 2019 

From: Irvine, California

Joined David Lab: January 2021

Outside of lab: working out, watching TV

Research in David Lab:

In the lab, I utilize techniques in molecular and structural biology, protein biochemistry and enzymology. These skills were cultivated and applied in the process of solving the first full-length structure of an important human base excision repair glycosylase, MUTYH. This work has enabled us to characterize many functional features of the enzyme but has raised additional questions pertaining to the coordination of a zinc ion which is missing from the structure. My current work involves characterizing the structural motif that binds zinc, as well as characterizing naturally occurring cancer variants surrounding this motif. Our structure of MUTYH has also informed a second project, involving the potential discovery of a small molecule inhibitor that binds to a C-terminal substrate recognition motif, thereby diminishing enzymatic activity.

RSS Science Daily News

  • 'Dancing molecules' heal cartilage damage July 26, 2024
    New therapy uses synthetic nanofibers to mimic the natural signaling of a protein that is crucial for cartilage formation and maintenance. Researchers found that intensifying the motion of molecules within the nanofibers led to more components needed for regeneration. After just four hours, the treatment activated the gene expression necessary to generate cartilage. Therapy could […]
  • New understanding of fly behavior has potential application in robotics, public safety July 26, 2024
    Scientists have identified an automatic behavior in flies that helps them assess wind conditions -- its presence and direction -- before deploying a strategy to follow a scent to its source. The fact that they can do this is surprising -- can you tell if there's a gentle breeze if you stick your head out […]
  • Lampreys possess a 'jaw-dropping' evolutionary origin July 26, 2024
    Lampreys are one of only two living jawless vertebrates Jaws are formed by a key stem cell population called the neural crest New research reveals the gene regulatory changes that may explain morphological differences between jawed and jawless vertebrates.
  • Researchers develop state-of-the-art device to make artificial intelligence more energy efficient July 26, 2024
    Engineering researchers have demonstrated a state-of-the-art hardware device that could reduce energy consumption for artificial intelligent (AI) computing applications by a factor of at least 1,000.
  • New drug shows promise in clearing HIV from brain July 25, 2024
    An experimental drug originally developed to treat cancer may help clear HIV from infected cells in the brain, according to a new study. By targeting infected cells in the brain, drug may clear virus from hidden areas that have been a major challenge in HIV treatment.

Contact:

Dr. Sheila S. David
ssdavid@ucdavis.edu
(530)-752-4280

Department of Chemistry
One Shields Ave.
Davis, CA 95616