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Mo Hashemian

Mo Hashemian

Education: B.S. Biological Sciences, University of California, Irvine, 2019 

From: Irvine, California

Joined David Lab: January 2021

Outside of lab: working out, watching TV

Research in David Lab:

In the lab, I utilize techniques in molecular and structural biology, protein biochemistry and enzymology. These skills were cultivated and applied in the process of solving the first full-length structure of an important human base excision repair glycosylase, MUTYH. This work has enabled us to characterize many functional features of the enzyme but has raised additional questions pertaining to the coordination of a zinc ion which is missing from the structure. My current work involves characterizing the structural motif that binds zinc, as well as characterizing naturally occurring cancer variants surrounding this motif. Our structure of MUTYH has also informed a second project, involving the potential discovery of a small molecule inhibitor that binds to a C-terminal substrate recognition motif, thereby diminishing enzymatic activity.

RSS Science Daily News

  • Matching your workouts to your personality could make exercising more enjoyable and give you better results July 9, 2025
    Less than a quarter of us hit WHO activity targets, but a new UCL study suggests the trick may be matching workouts to our personalities: extroverts thrive in high-energy group sports, neurotics prefer private bursts with breaks, and everyone sees stress levels drop when they find exercise they enjoy.
  • Scientists just recreated a 1938 experiment that could rewrite fusion history July 9, 2025
    A groundbreaking collaboration between Los Alamos scientists and Duke University has resurrected a nearly forgotten 1938 experiment that may have quietly sparked the age of fusion energy. Arthur Ruhlig, a little-known physicist, first observed signs of deuterium-tritium (DT) fusion nearly a decade before its significance became clear in nuclear science. The modern team not only […]
  • Astronomers Catch Planets in the Act of Being Born July 9, 2025
    Astronomers have spotted centimeter-sized “pebbles” swirling around two infant stars 450 light-years away, revealing the raw ingredients of planets already stretching to Neptune-like orbits. Using the UK’s e-MERLIN radio array, the PEBBLeS project found these rocky seeds in unprecedented detail, bridging the elusive gap between dusty discs and fully-formed worlds. The discovery hints that systems […]
  • Ice in a million-degree Fermi bubble reveals the Milky Way’s recent eruption July 9, 2025
    Astronomers using the Green Bank Telescope spotted surprisingly cold, dense hydrogen clouds embedded inside the Milky Way’s vast, super-hot Fermi bubbles—structures thought to be created by a recent, violent outburst from the galaxy’s core. Because such chilled gas should evaporate quickly in million-degree surroundings, its survival hints that the bubbles are only about a million […]
  • Hidden DNA-sized crystals in cosmic ice could rewrite water—and life itself July 9, 2025
    Scientists from UCL and the University of Cambridge have revealed that "space ice"—long thought to be completely disordered—is actually sprinkled with tiny crystals, changing our fundamental understanding of ice in the cosmos. These micro-crystals, just nanometers wide, were identified through simulations and lab experiments, revealing that even the most common ice in space retains a […]

Contact:

Dr. Sheila S. David
ssdavid@ucdavis.edu
(530)-752-4280

Department of Chemistry
One Shields Ave.
Davis, CA 95616