Just Accepted Manuscript: Structure Activity Relationships Reveal Key Features of 8-Oxoguanine:Adenine Mismatch Detection by the MutY DNA Glycosylase
7/20/2017
The recently accepted manuscript, Structure Activity Relationships Reveal Key Features of 8-Oxoguanine:Adenine Mismatch Detection by the MutY DNA Glycosylase, was accepted for publication in ACS Chemical Biology.
MutY, remarkably, is able to specifically recognize and initiate repair of target OG:A mismatches from among a vast sea of natural DNA. To help reveal molecular features of OG that are critical for MutY recognition, this work explored the effects of systematic OG:A substrate alterations on MutY recognition in a cellular context. OG analogs were synthesized, assembled into OG:A modified oligonucleotides, and structure activity relationships were investigated using binding and cellular repair assays. Read the article to find out more about how specific OG modifications effect MutY glycosylase activity. Click here for the article: http://pubs.acs.org/doi/abs/10.1021/acschembio.7b00389.
Keywords: #Muty #DNA #DNARepair #BER #ModifiedNucleosides #Enzymes #8OG #DavidLab #UCDavis #glycosylase
Just Accepted Manuscript: S K-edge XAS Studies of the Effect of DNA Binding on the [Fe4S4] Site in EndoIII and MutY
7/18/2017
Check out the latest manuscript from the David Lab and collaborators: S K-edge XAS Studies of the Effect of DNA Binding on the [Fe4S4] Site in EndoIII and MutY, which was recently accepted for publication in JACS. In this work, the iron-sulfur clusters of DNA repair glycosylases Endonuclease III and MutY were examined using S K-edge X-ray Absorption Spectroscopy (XAS) in order to investigate DNA binding and solvation effects on Fe-S bond covalencies.
Click below to view the manuscript:
http://pubs.acs.org/doi/abs/10.1021/jacs.7b03966
Dare to Repair with Nicole Nuñez
6/6/2017
Take a walk with Nicole Nuñez as she illustrates how the David Lab investigates DNA repair.
Congratulations to Doug Banda and coworkers!
5/31/2017
Congratulations to David Lab authors Doug, Nicole, Michael, and Katie on their recently released article, “Repair of 8-OXOG:A Mismatches by the MUTYH Glycosylase: Mechanisms, Metals and Medicine,” in Free Radical Biology and Medicine! The final version of the article is now available online.
Link to their new article here: https://authors.elsevier.com/a/1V8Lr3AkHAI6DS.
Science Daily News
- Listening to electrons talk May 29, 2025Researchers present new experimental and theoretical results for the bound electron g-factor in lithium-like tin which has a much higher nuclear charge than any previous measurement. The experimental accuracy reached a level of 0.5 parts per billion. Using an enhanced interelectronic QED method, the theoretical prediction for the g-factor reached a precision of 6 parts […]
- Save twice the ice by limiting global warming May 29, 2025A new study finds that if global warming exceeds the Paris Climate Agreement targets, the non-polar glacier mass will diminish significantly. However, if warming is limited to 1.5 degrees Celsius, at least 54 per cent could be preserved -- more than twice as much ice as in a 2.7 C scenario.
- Birds nested in Arctic alongside dinosaurs May 29, 2025Spring in the Arctic brings forth a plethora of peeps and downy hatchlings as millions of birds gather to raise their young. The same was true 73 million years ago, according to a new article. The paper documents the earliest-known example of birds nesting in the polar regions.
- Leprosy existed in America long before arrival of Europeans May 29, 2025Long considered a disease brought to the Americas by European colonizers, leprosy may actually have a much older history on the American continent. Scientists reveal that a recently identified second species of bacteria responsible for leprosy, Mycobacterium lepromatosis, has been infecting humans in the Americas for at least 1,000 years, several centuries before the Europeans […]
- Anthropologists spotlight human toll of glacier loss May 29, 2025Anthropologists have examined the societal consequences of global glacier loss.