Home » Nikole Tamayo

Nikole Tamayo

Personal Information

Name: Nikole Tamayo

Education: Bachelor’s of Science in Chemistry, ACS Certified in Biochemistry

Minor in Biology, Southern Oregon University

From: Las Vegas, NV

Joined the David Lab: January 2020

Enjoys outside of lab: Video games, bullet journaling, and hiking

Research in the David Lab:

In DNA, guanine is the most susceptible to oxidation and its oxidation product is 8-oxo-7,8-dihydro-oxoguanine (OG). The Hoogsteen face of OG is similar to thymine (T) so during replication adenine (A) is misincorporated and after another round of replication results in a G:C to T:A transversion mutation. MutY is a DNA base excision repair enzyme that removes A from OG. Part of the enzyme that is theorized to recognize DNA lesions and facilitate repair is the iron-sulfur cluster. Nikole is investigating the role of the iron-sulfur cluster by examining “clusterless” enzymes, enzymes that do not contain the iron-sulfur cluster based on sequence homology. The lack of the iron-sulfur cluster suggests that it may not be necessary for DNA repair and recognition.

Previous Research Experience:

Nikole participated in two summer research internships while attending Southern Oregon University. At the Medical University of South Carolina, Nikole learned about hematopoietic stem cells and their ability to differentiate into many different cell types including blood cells, mast cells, and osteoclasts. Nikole learned how to culture specialized cells and image them, process tissues, section tissues, immunohistochemistry staining for tissues and stem cells, and bone marrow extraction from mice and staining for flow cytometry. At the University of Arizona, Nikole learned about short and long cell signaling in plants how errors in the clavata-wuschel pathway can affect the meristem and the fruit of plants in Arabidopsis or tomatoes. Nikole learned how to extract plant DNA, create polymerase chain reaction methods for specific primers, and interpret and image gels from gel electrophoresis. For Nikole’s undergraduate research at Southern Oregon University, she investigated the stability of epinephrine under various environmental conditions. She adapted a previously published method on quantifying the degradation products of epinephrine using high performance liquid chromatography and how to analyze the results to yield relative concentrations of epinephrine and its degradation products.

RSS Science Daily News

  • New Orleans is sinking—and so are its $15 billion flood defenses June 29, 2025
    Parts of New Orleans are sinking at alarming rates — including some of the very floodwalls built to protect it. A new satellite-based study finds that some areas are losing nearly two inches of elevation per year, threatening the effectiveness of the city's storm defenses.
  • Record-breaking 10-billion-year radio halo just rewrote the universe’s origin story June 28, 2025
    A newly discovered radio halo, 10 billion light-years away, reveals that galaxy clusters in the early universe were already steeped in high-energy particles. The finding hints at ancient black hole activity or cosmic particle collisions fueling this energy.
  • A mysterious mineral in asteroid Ryugu may rewrite planetary history June 28, 2025
    A surprising discovery from a tiny grain of asteroid Ryugu has rocked scientists' understanding of how our Solar System evolved. Researchers found djerfisherite—a mineral typically born in scorching, chemically reduced conditions and never before seen in Ryugu-like meteorites—inside a sample returned by Japan’s Hayabusa2 mission. Its presence suggests either Ryugu once experienced unexpectedly high temperatures […]
  • A giant pulse beneath Africa could split the continent — and form an ocean June 27, 2025
    Beneath the Afar region in Ethiopia, scientists have discovered pulsing waves of molten rock rising from deep within the Earth — a geological heartbeat that could eventually split Africa in two. These rhythmic surges of mantle material are helping to stretch and thin the continent’s crust, setting the stage for a new ocean to form […]
  • World’s largest camera just snapped the Universe in 3,200 megapixels June 27, 2025
    The LSST camera at the Vera C. Rubin Observatory has released its jaw-dropping first images, each capturing 45 times the area of the full moon in one shot. Over the next ten years, this cosmic giant will scan the southern sky in ultra-HD, helping scientists uncover everything from asteroids to the secrets of dark energy.

Contact:

Dr. Sheila S. David
ssdavid@ucdavis.edu
(530)-752-4280

Department of Chemistry
One Shields Ave.
Davis, CA 95616