Home » Steven Merrill

Steven Merrill

Steven Merrill

Education:

B.S. Biochemistry, California State San Bernardino 2016, Magna Cum Laude

From: Chino, California

Joined David Lab: January 2019

Outside of lab: Exploring the Davis area with my wife, exercising, or catching up on the latest Marvel project (:

Research in the David Lab:

Oxidative DNA damage requires repairment to maintain genomic integrity. The Base excision repair pathway is initiated to remove undesirable nucleobases and inserts proper nucleobase. The pathway is initiated by a class of enzymes known as DNA glycosylases- initiation occurs following the identification and excision of an aberrant nucleobase. In case of the DNA glycosylase MutY, MUTYH in humans, the base to be removed is adenine following it’s misplacement across an oxidized guanine during replication. My work in the David lab is aimed to further explore and develop a model for early nucleobase identification and verification- processes that occur prior to but demonstrate to be influential in set up for proper catalysis. Specific residues investigated as part of this work are in conserved motifs of various MutY orthologues and curiously a subset of these residues have variants in which there is a suspicion of elevated cancer susceptibility. My work has a combined structural, biochemical and cellular components to propose a comprehensive understanding of particular regions of interest within MutY.

RSS Science Daily News

  • A 3-minute brainwave test could spot Alzheimer’s years before symptoms September 4, 2025
    Scientists at the University of Bath have developed a simple three-minute brainwave test called Fastball EEG that can detect memory problems years before Alzheimer’s is typically diagnosed. Unlike traditional memory tests, it passively records brain responses to images and has now been proven effective in people’s homes. With breakthrough Alzheimer’s drugs working best in early […]
  • Scientists watch an atomic nucleus flip in real time September 4, 2025
    Scientists at Delft University of Technology have managed to watch a single atomic nucleus flip its magnetic state in real time. Using a scanning tunneling microscope, they indirectly read the nucleus through its electrons, finding the nuclear spin surprisingly stable for several seconds. This “single-shot readout” breakthrough could pave the way for manipulating atomic-scale quantum […]
  • Fossil reveals a 310-million-year-old fish that ate with a hidden second jaw September 4, 2025
    Scientists uncovered a 310-million-year-old fish fossil with a “tongue bite,” teeth on the roof and floor of its mouth that worked like a second jaw. This adaptation, previously thought to have appeared much later, shows how fish rapidly experimented with new feeding strategies after mass extinction.
  • Scientists create biodegradable plastic stronger than PET September 4, 2025
    A Japanese research team successfully harnessed E. coli to produce PDCA, a strong, biodegradable plastic alternative. Their method avoids toxic byproducts and achieves record production levels, overcoming key roadblocks with creative fixes.
  • A tiny embryo fold changed the course of evolution September 4, 2025
    A small tissue fold in fly embryos, once thought purposeless, plays a vital role in stabilizing tissues. Researchers show that it absorbs stress during early development, and its position and timing likely shaped its evolutionary emergence.

Contact:

Dr. Sheila S. David
ssdavid@ucdavis.edu
(530)-752-4280

Department of Chemistry
One Shields Ave.
Davis, CA 95616