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Steven Merrill

Steven Merrill

Education:

B.S. Biochemistry, California State San Bernardino 2016, Magna Cum Laude

From: Chino, California

Joined David Lab: January 2019

Outside of lab: Exploring the Davis area with my wife, exercising, or catching up on the latest Marvel project (:

Research in the David Lab:

Oxidative DNA damage requires repairment to maintain genomic integrity. The Base excision repair pathway is initiated to remove undesirable nucleobases and inserts proper nucleobase. The pathway is initiated by a class of enzymes known as DNA glycosylases- initiation occurs following the identification and excision of an aberrant nucleobase. In case of the DNA glycosylase MutY, MUTYH in humans, the base to be removed is adenine following it’s misplacement across an oxidized guanine during replication. My work in the David lab is aimed to further explore and develop a model for early nucleobase identification and verification- processes that occur prior to but demonstrate to be influential in set up for proper catalysis. Specific residues investigated as part of this work are in conserved motifs of various MutY orthologues and curiously a subset of these residues have variants in which there is a suspicion of elevated cancer susceptibility. My work has a combined structural, biochemical and cellular components to propose a comprehensive understanding of particular regions of interest within MutY.

RSS Science Daily News

  • Life on Mars? NASA discovers potential biosignatures in Martian mudstones September 11, 2025
    NASA’s Perseverance rover has discovered mudstones in Mars’ Jezero Crater that contain organic carbon and unusual textures hinting at possible biosignatures. These findings suggest that ancient Martian environments may have supported chemical processes similar to those on Earth, where microbial life thrives. While the team stresses they have not discovered evidence of life, the rocks […]
  • Surprising gut discovery reveals a hidden trigger of diabetes and liver disease September 11, 2025
    Scientists in Canada have uncovered a surprising culprit behind high blood sugar and liver problems: a hidden fuel made by gut bacteria. This little-known molecule, called D-lactate, slips into the bloodstream and pushes the liver to make too much sugar and fat. By creating a simple “trap” that blocks the molecule in the gut, researchers […]
  • Mapping the secret escape routes of deadly brain tumors September 11, 2025
    Glioblastoma’s stealthy spread has met a new challenge: MRI-powered fluid flow mapping that reveals where the cancer is likely to invade next. The innovation is now being advanced by a spinoff company to guide personalized cancer treatments.
  • Who were the mystery humans behind Indonesia’s million-year-old tools? September 10, 2025
    A groundbreaking discovery on the Indonesian island of Sulawesi reveals that early hominins crossed treacherous seas over a million years ago, leaving behind stone tools that reshape our understanding of ancient migration. These findings, older than previous evidence in the region, highlight Sulawesi as a critical piece of the puzzle in human evolution. Yet, the […]
  • Scientists just built a detector that could finally catch dark matter September 10, 2025
    Physicists have unveiled a new superconducting detector sensitive enough to hunt dark matter particles smaller than electrons. By capturing faint photon signals, the device pushes the search into uncharted territory.

Contact:

Dr. Sheila S. David
ssdavid@ucdavis.edu
(530)-752-4280

Department of Chemistry
One Shields Ave.
Davis, CA 95616