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Steven Merrill

Steven Merrill

Education:

B.S. Biochemistry, California State San Bernardino 2016, Magna Cum Laude

From: Chino, California

Joined David Lab: January 2019

Outside of lab: Exploring the Davis area with my wife, exercising, or catching up on the latest Marvel project (:

Research in the David Lab:

Oxidative DNA damage requires repairment to maintain genomic integrity. The Base excision repair pathway is initiated to remove undesirable nucleobases and inserts proper nucleobase. The pathway is initiated by a class of enzymes known as DNA glycosylases- initiation occurs following the identification and excision of an aberrant nucleobase. In case of the DNA glycosylase MutY, MUTYH in humans, the base to be removed is adenine following it’s misplacement across an oxidized guanine during replication. My work in the David lab is aimed to further explore and develop a model for early nucleobase identification and verification- processes that occur prior to but demonstrate to be influential in set up for proper catalysis. Specific residues investigated as part of this work are in conserved motifs of various MutY orthologues and curiously a subset of these residues have variants in which there is a suspicion of elevated cancer susceptibility. My work has a combined structural, biochemical and cellular components to propose a comprehensive understanding of particular regions of interest within MutY.

RSS Science Daily News

  • Frozen for 12,000 years, this Alpine ice core captures the rise of civilization July 17, 2025
    An ancient glacier high in the French Alps has revealed the oldest known ice in Western Europe—dating back over 12,000 years to the last Ice Age. This frozen archive, meticulously analyzed by scientists, captures a complete chemical and atmospheric record spanning humanity’s transition from hunter-gatherers to modern industry. The core contains stories of erupting volcanoes, […]
  • They fled the flames—now jaguars rule a wetland refuge July 17, 2025
    After devastating wildfires scorched the Brazilian Pantanal, an unexpected phenomenon unfolded—more jaguars began arriving at a remote wetland already known for having the densest jaguar population on Earth. Scientists discovered that not only did the local jaguars survive, but their numbers swelled as migrants sought refuge. This unique ecosystem, where jaguars feast mainly on fish […]
  • Dogs can detect Parkinson’s years before symptoms—with 98% accuracy July 16, 2025
    Dogs trained to detect Parkinson’s disease using scent have shown remarkable accuracy in new research. In a double-blind trial, they identified skin swabs from people with Parkinson’s with up to 80% sensitivity and 98% specificity, even when other health conditions were present. The findings offer hope for a simple, non-invasive diagnostic method using biomarkers that […]
  • This laser implosion just created a magnetic field like a neutron star July 16, 2025
    A powerful new technique harnesses swirling plasma inside laser-blasted microtubes to produce record-breaking magnetic fields—rivaling those near neutron stars—all within a compact laboratory setup. This innovation promises to transform astrophysics, quantum research, and fusion energy experiments by unleashing megatesla-level forces using nothing more than targeted laser pulses and clever engineering.
  • Scholars just solved a 130-year literary mystery—and it all hinged on one word July 16, 2025
    After baffling scholars for over a century, Cambridge researchers have reinterpreted the long-lost Song of Wade, revealing it to be a chivalric romance rather than a monster-filled myth. The twist came when “elves” in a medieval sermon were correctly identified as “wolves,” dramatically altering the legend’s tone and context.

Contact:

Dr. Sheila S. David
ssdavid@ucdavis.edu
(530)-752-4280

Department of Chemistry
One Shields Ave.
Davis, CA 95616