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Steven Merrill

Steven Merrill

Education:

B.S. Biochemistry, California State San Bernardino 2016, Magna Cum Laude

From: Chino, California

Joined David Lab: January 2019

Outside of lab: Exploring the Davis area with my wife, exercising, or catching up on the latest Marvel project (:

Research in the David Lab:

Oxidative DNA damage requires repairment to maintain genomic integrity. The Base excision repair pathway is initiated to remove undesirable nucleobases and inserts proper nucleobase. The pathway is initiated by a class of enzymes known as DNA glycosylases- initiation occurs following the identification and excision of an aberrant nucleobase. In case of the DNA glycosylase MutY, MUTYH in humans, the base to be removed is adenine following it’s misplacement across an oxidized guanine during replication. My work in the David lab is aimed to further explore and develop a model for early nucleobase identification and verification- processes that occur prior to but demonstrate to be influential in set up for proper catalysis. Specific residues investigated as part of this work are in conserved motifs of various MutY orthologues and curiously a subset of these residues have variants in which there is a suspicion of elevated cancer susceptibility. My work has a combined structural, biochemical and cellular components to propose a comprehensive understanding of particular regions of interest within MutY.

RSS Science Daily News

  • One shot, seven days: Long-acting levodopa gel tackles Parkinson’s tremors July 14, 2025
    Researchers in Australia have created a biodegradable gel that delivers Parkinson’s medications through a single weekly shot, replacing the need for multiple daily pills. Injected just under the skin, the gel steadily releases levodopa and carbidopa for seven days, helping keep tremors and stiffness in check while easing side effects linked to fluctuating doses.
  • Can zebrafish help humans regrow hearing cells? July 14, 2025
    Zebrafish can regenerate sensory hair cells that humans permanently lose, like those in the inner ear linked to hearing and balance. New research reveals two specific genes that control how different supporting cells in zebrafish divide and regenerate, offering clues to how mammals might someday tap into similar regenerative powers.
  • It looked like nothing—then scientists found a world 10x the size of Jupiter July 14, 2025
    Astronomers have uncovered a massive, hidden exoplanet nestled in the dusty disc of a young star—MP Mus—by combining cutting-edge data from the ALMA observatory and ESA’s Gaia mission. Initially thought to be planet-free, the star’s surrounding disc appeared deceptively empty. But new observations and a telltale stellar “wobble” pointed to a Jupiter-sized gas giant forming […]
  • This AI-powered lab runs itself—and discovers new materials 10x faster July 14, 2025
    A new leap in lab automation is shaking up how scientists discover materials. By switching from slow, traditional methods to real-time, dynamic chemical experiments, researchers have created a self-driving lab that collects 10 times more data, drastically accelerating progress. This new system not only saves time and resources but also paves the way for faster […]
  • This Algorithm Just Solved One of Physics’ Most Infamous Problems July 14, 2025
    Using an advanced Monte Carlo method, Caltech researchers found a way to tame the infinite complexity of Feynman diagrams and solve the long-standing polaron problem, unlocking deeper understanding of electron flow in tricky materials.

Contact:

Dr. Sheila S. David
ssdavid@ucdavis.edu
(530)-752-4280

Department of Chemistry
One Shields Ave.
Davis, CA 95616