Home » Posts tagged 'Zn2+'
Tag Archives: Zn2+
New Manuscript Published: The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair.
New Manuscript Published: The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair.
A recent publication from the David, Siegel and Lim (Academia Sinica, Taiwan) labs (Nuñez et al., JACS, 2018) provides insight into the coordination sphere and critical role of a Zn2+ metal binding site in the DNA repair glycosylase MUTYH. Genome database mining and sequence alignment of MUTYH orthologs, along with computational modeling, identified and supported Zn2+ ligation by four Cys residues. Three of the Cys residues lie in an interdomain connector region unique to mammalian MutY enzymes, while the 4th Cys is located in close proximity to the Fe-S cluster DNA binding domain. The functional consequences of reduced Zn2+ chelation on MUTYH-mediated DNA repair activity evaluated using a battery of in vitro and cell-based assays revealed the importance of Zn-coordination in recognition of the damaged DNA substrate. The critical nature of the “Zinc Linchpin Motif” suggests additional functions unique to higher organisms in damage signaling and crosstalk with other DNA repair pathways.
More information at https://pubs.acs.org/doi/10.1021/jacs.8b06923.
Source:
J. Am. Chem. Soc. 2018, 140, 13260-13271.
Keywords: #Muty #Mutyh #BER #DNA #DNARepair #ZincLinchpinMotif #Zn2+ #8OG #DavidLab #UCDavis
Science Daily News
- Floating solar panels could support US energy goals January 14, 2025Federal reservoirs could help meet the country's solar energy needs, according to a new study. Geospatial scientists and senior legal and regulatory analyst quantified exactly how much energy could be generated from floating solar panel projects installed on federally owned or regulated reservoirs.
- Residents of unburned homes reported health symptoms months after Marshall Fire January 14, 2025Wildfires that burn homes and vehicles could expose people to dangerous airborne compounds through ash and smoke. Research has shown that people returning to their unburned homes may also experience health symptoms months after a nearby fire is extinguished. Through a survey of people affected by the 2021 Marshall Fire in Boulder, Colorado, researchers found […]
- World's oldest 3D map discovered January 14, 2025Researchers have discovered what may be the world's oldest three-dimensional map, located within a quartzitic sandstone megaclast in the Paris Basin.
- Engineering quantum entanglement at the nanoscale January 14, 2025Researchers have developed a drastically smaller and more energy efficient method of creating coveted photon pairs that influence each other from any distance. The technology could transform computing, telecommunications, and sensing.
- NASA's Hubble tracks down a 'blue lurker' among stars January 13, 2025The name 'blue lurker' might sound like a villainous character from a superhero movie. But it is a rare class of star that NASA's Hubble Space Telescope explored by looking deeply into the open star cluster M67, roughly 2,800 light-years away.