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Recent Article Published: Unique H-bonding of Adenine with oxidatively damaged base 8-oxoguanosine enables specific recognition and repair by DNA glycosylase MutY.
Recent Article Published by Sheila David’s Lab: Unique Hydrogen Bonding of Adenine with the Oxidatively Damaged Base 8-Oxoguanine Enables Specific Recognition and Repair by DNA Glycosylase MutY. Majumdar, C.; Mckibbin, P.L.; Krajewski, A.E.; Manlove, A.H.; Lee, J.K.; David, S.S. J. Am. Soc. 2020. 142, 48, 20340–20350. DNA repair protein MutY employs specific […]
New Manuscript Published: The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair.
New Manuscript Published: The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair. A recent publication from the David, Siegel and Lim (Academia Sinica, Taiwan) labs (Nuñez et al., JACS, 2018) provides insight into the coordination sphere and critical role of a Zn2+ metal […]
New Manuscript Published: Selective base excision repair of DNA damage by the non‐base‐flipping DNA glycosylase AlkC.
New Manuscript Published: Selective base excision repair of DNA damage by the non‐base‐flipping DNA glycosylase AlkC. The preservation of genomic integrity performed by DNA repair machinery is crucial for living organisms, and malfunctions in DNA repair machinery can have far-reaching and devastating effects on a cell’s ability to attain precise DNA replication, properly regulate cell […]
Just Accepted Manuscript: Structure Activity Relationships Reveal Key Features of 8-Oxoguanine:Adenine Mismatch Detection by the MutY DNA Glycosylase
7/20/2017 The recently accepted manuscript, Structure Activity Relationships Reveal Key Features of 8-Oxoguanine:Adenine Mismatch Detection by the MutY DNA Glycosylase, was accepted for publication in ACS Chemical Biology. MutY, remarkably, is able to specifically recognize and initiate repair of target OG:A mismatches from among a vast sea of natural DNA. To help reveal molecular features of […]
Congratulations to Doug Banda and coworkers!
5/31/2017 Congratulations to David Lab authors Doug, Nicole, Michael, and Katie on their recently released article, “Repair of 8-OXOG:A Mismatches by the MUTYH Glycosylase: Mechanisms, Metals and Medicine,” in Free Radical Biology and Medicine! The final version of the article is now available online. Link to their new article here: https://authors.elsevier.com/a/1V8Lr3AkHAI6DS.
Science Daily News
- Why Alzheimer’s attacks the brain’s memory hub first September 3, 2025Virginia Tech researchers are investigating how overloaded mitochondria in the brain’s memory circuits may spark early Alzheimer’s damage. Their work focuses on calcium signaling and how it might trigger breakdowns in the entorhinal cortex.
- Warped planet nurseries rewrite the rules of how worlds are born September 3, 2025Astronomers using ALMA have discovered that planet-forming discs are not flat and serene but subtly warped, reshaping our understanding of how planets form. These slight tilts, similar to those seen among planets in our Solar System, suggest that planetary systems emerge in more chaotic and dynamic conditions than once believed. The findings point to new […]
- Distant suns covered in dark spots could shape the search for life September 2, 2025A new model called StarryStarryProcess lets scientists map star spots with precision, improving how exoplanets are studied. By factoring in both transits and stellar rotation, it provides richer details about stars and their influence on planetary signals.
- NASA’s SPHEREx Captures Comet 3I/ATLAS, a Visitor From Beyond the Solar System September 2, 2025NASA’s SPHEREx joined Webb and Hubble in studying interstellar comet 3I/ATLAS, gathering data on its size, chemistry, and physical traits. While harmless to Earth, the comet provides scientists a rare opportunity to learn more about solar system wanderers.
- Scientists discover how to wipe out breast cancer’s hidden cells September 2, 2025Scientists at the University of Pennsylvania have shown for the first time that it’s possible to detect dormant cancer cells in breast cancer survivors and eliminate them with repurposed drugs, potentially preventing recurrence. In a clinical trial, existing medications cleared these hidden cells in most participants, leading to survival rates above 90%. The findings open […]