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Tag Archives: DNA Repair
Recent Article Published: Unique H-bonding of Adenine with oxidatively damaged base 8-oxoguanosine enables specific recognition and repair by DNA glycosylase MutY.
Recent Article Published by Sheila David’s Lab: Unique Hydrogen Bonding of Adenine with the Oxidatively Damaged Base 8-Oxoguanine Enables Specific Recognition and Repair by DNA Glycosylase MutY. Majumdar, C.; Mckibbin, P.L.; Krajewski, A.E.; Manlove, A.H.; Lee, J.K.; David, S.S. J. Am. Soc. 2020. 142, 48, 20340–20350. DNA repair protein MutY employs specific […]
New Manuscript Published: The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair.
New Manuscript Published: The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair. A recent publication from the David, Siegel and Lim (Academia Sinica, Taiwan) labs (Nuñez et al., JACS, 2018) provides insight into the coordination sphere and critical role of a Zn2+ metal […]
New Manuscript Published: Selective base excision repair of DNA damage by the non‐base‐flipping DNA glycosylase AlkC.
New Manuscript Published: Selective base excision repair of DNA damage by the non‐base‐flipping DNA glycosylase AlkC. The preservation of genomic integrity performed by DNA repair machinery is crucial for living organisms, and malfunctions in DNA repair machinery can have far-reaching and devastating effects on a cell’s ability to attain precise DNA replication, properly regulate cell […]
Just Accepted Manuscript: Structure Activity Relationships Reveal Key Features of 8-Oxoguanine:Adenine Mismatch Detection by the MutY DNA Glycosylase
7/20/2017 The recently accepted manuscript, Structure Activity Relationships Reveal Key Features of 8-Oxoguanine:Adenine Mismatch Detection by the MutY DNA Glycosylase, was accepted for publication in ACS Chemical Biology. MutY, remarkably, is able to specifically recognize and initiate repair of target OG:A mismatches from among a vast sea of natural DNA. To help reveal molecular features of […]
Congratulations to Doug Banda and coworkers!
5/31/2017 Congratulations to David Lab authors Doug, Nicole, Michael, and Katie on their recently released article, “Repair of 8-OXOG:A Mismatches by the MUTYH Glycosylase: Mechanisms, Metals and Medicine,” in Free Radical Biology and Medicine! The final version of the article is now available online. Link to their new article here: https://authors.elsevier.com/a/1V8Lr3AkHAI6DS.
Science Daily News
- NASA’s Perseverance just found new evidence that Mars could have been habitable September 18, 2025Jezero Crater’s rocks reveal three stages of water activity, shifting from hostile acidic fluids to more life-friendly alkaline ones. Perseverance’s discoveries guide future sampling and strengthen the hunt for past life on Mars.
- The Moon could finally reveal dark matter September 18, 2025Faint hydrogen signals from the cosmic Dark Ages may soon help determine the mass of dark matter particles. Simulations suggest future Moon-based observatories could distinguish between warm and cold dark matter, providing long-sought answers about the invisible backbone of the Universe.
- White dwarf caught devouring a frozen Pluto-like world September 18, 2025Astronomers have detected the chemical fingerprint of a frozen, water-rich planetary fragment being devoured by a white dwarf star, offering the clearest evidence yet that icy, life-delivering objects exist beyond our Solar System. The find suggests fragments like comets and dwarf planets may be common ingredients of planetary systems.
- Why Alaska’s salmon streams are suddenly bleeding orange September 18, 2025Warming Arctic permafrost is unlocking toxic metals, turning Alaska’s once-clear rivers into orange, acid-laced streams. The shift, eerily similar to mine pollution but entirely natural, threatens fish, ecosystems, and communities that depend on them—with no way to stop the process once it starts.
- Goodbye colonoscopy? Simple stool test detects 90% of colorectal cancers September 18, 2025Scientists at the University of Geneva have created the first detailed catalogue of gut bacteria at the subspecies level, unlocking powerful new ways to detect colorectal cancer. By applying machine learning to stool samples, they achieved a 90% detection rate—nearly matching colonoscopies, but with far less cost and discomfort. This breakthrough could revolutionize early cancer […]