Home » Posts tagged 'DNA Repair'
Tag Archives: DNA Repair
Recent Article Published: Unique H-bonding of Adenine with oxidatively damaged base 8-oxoguanosine enables specific recognition and repair by DNA glycosylase MutY.
Recent Article Published by Sheila David’s Lab: Unique Hydrogen Bonding of Adenine with the Oxidatively Damaged Base 8-Oxoguanine Enables Specific Recognition and Repair by DNA Glycosylase MutY. Majumdar, C.; Mckibbin, P.L.; Krajewski, A.E.; Manlove, A.H.; Lee, J.K.; David, S.S. J. Am. Soc. 2020. 142, 48, 20340–20350. DNA repair protein MutY employs specific […]
New Manuscript Published: The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair.
New Manuscript Published: The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair. A recent publication from the David, Siegel and Lim (Academia Sinica, Taiwan) labs (Nuñez et al., JACS, 2018) provides insight into the coordination sphere and critical role of a Zn2+ metal […]
New Manuscript Published: Selective base excision repair of DNA damage by the non‐base‐flipping DNA glycosylase AlkC.
New Manuscript Published: Selective base excision repair of DNA damage by the non‐base‐flipping DNA glycosylase AlkC. The preservation of genomic integrity performed by DNA repair machinery is crucial for living organisms, and malfunctions in DNA repair machinery can have far-reaching and devastating effects on a cell’s ability to attain precise DNA replication, properly regulate cell […]
Just Accepted Manuscript: Structure Activity Relationships Reveal Key Features of 8-Oxoguanine:Adenine Mismatch Detection by the MutY DNA Glycosylase
7/20/2017 The recently accepted manuscript, Structure Activity Relationships Reveal Key Features of 8-Oxoguanine:Adenine Mismatch Detection by the MutY DNA Glycosylase, was accepted for publication in ACS Chemical Biology. MutY, remarkably, is able to specifically recognize and initiate repair of target OG:A mismatches from among a vast sea of natural DNA. To help reveal molecular features of […]
Congratulations to Doug Banda and coworkers!
5/31/2017 Congratulations to David Lab authors Doug, Nicole, Michael, and Katie on their recently released article, “Repair of 8-OXOG:A Mismatches by the MUTYH Glycosylase: Mechanisms, Metals and Medicine,” in Free Radical Biology and Medicine! The final version of the article is now available online. Link to their new article here: https://authors.elsevier.com/a/1V8Lr3AkHAI6DS.
Science Daily News
- The bright yellow worm that turns ocean poison into golden survival crystals August 27, 2025Deep beneath the Pacific Ocean, a bright yellow worm thrives where no other animals dare, in toxic hydrothermal vents saturated with arsenic and sulfide. By cleverly turning these poisons into a golden mineral once prized by Renaissance painters, the worm neutralizes the deadly threat and survives in one of Earth’s most hostile habitats. Scientists say […]
- The ancient oxygen flood that forever changed life in the oceans August 27, 2025Ancient forests may have fueled a deep-sea oxygen boost nearly 390 million years ago, unlocking evolutionary opportunities for jawed fish and larger marine animals. New isotopic evidence shows that this permanent oxygenation marked a turning point in Earth’s history — a reminder of how fragile the ocean’s oxygen balance remains today.
- Scientists just created spacetime crystals made of knotted light August 27, 2025Researchers have developed a blueprint for weaving hopfions—complex, knot-like light structures—into repeating spacetime crystals. By exploiting two-color beams, they can generate ordered chains and lattices with tunable topology, potentially revolutionizing data storage, communications, and photonic processing.
- Tiny hologram inside a fiber lets scientists control light with incredible precision August 27, 2025Researchers in Germany have unveiled the Metafiber, a breakthrough device that allows ultra-precise, rapid, and compact control of light focus directly within an optical fiber. Unlike traditional systems that rely on bulky moving parts, the Metafiber uses a tiny 3D nanoprinted hologram on a dual-core fiber to steer light by adjusting power between its cores. […]
- This tiny iron catalyst could transform the future of clean energy August 27, 2025Hydrogen fuel cells could power cars, devices, and homes with nothing but water as a byproduct—but platinum’s cost holds them back. Chinese researchers have now unveiled a breakthrough iron-based catalyst that could rival platinum while boosting efficiency and durability. With its clever “inner activation, outer protection” design, this new catalyst not only reduces harmful byproducts […]