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Recent Article Published: Unique H-bonding of Adenine with oxidatively damaged base 8-oxoguanosine enables specific recognition and repair by DNA glycosylase MutY.
Recent Article Published by Sheila David’s Lab: Unique Hydrogen Bonding of Adenine with the Oxidatively Damaged Base 8-Oxoguanine Enables Specific Recognition and Repair by DNA Glycosylase MutY. Majumdar, C.; Mckibbin, P.L.; Krajewski, A.E.; Manlove, A.H.; Lee, J.K.; David, S.S. J. Am. Soc. 2020. 142, 48, 20340–20350. DNA repair protein MutY employs specific […]
New Manuscript Published: The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair.
New Manuscript Published: The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair. A recent publication from the David, Siegel and Lim (Academia Sinica, Taiwan) labs (Nuñez et al., JACS, 2018) provides insight into the coordination sphere and critical role of a Zn2+ metal […]
Just Accepted Manuscript: Structure Activity Relationships Reveal Key Features of 8-Oxoguanine:Adenine Mismatch Detection by the MutY DNA Glycosylase
7/20/2017 The recently accepted manuscript, Structure Activity Relationships Reveal Key Features of 8-Oxoguanine:Adenine Mismatch Detection by the MutY DNA Glycosylase, was accepted for publication in ACS Chemical Biology. MutY, remarkably, is able to specifically recognize and initiate repair of target OG:A mismatches from among a vast sea of natural DNA. To help reveal molecular features of […]
Congratulations to Doug Banda and coworkers!
5/31/2017 Congratulations to David Lab authors Doug, Nicole, Michael, and Katie on their recently released article, “Repair of 8-OXOG:A Mismatches by the MUTYH Glycosylase: Mechanisms, Metals and Medicine,” in Free Radical Biology and Medicine! The final version of the article is now available online. Link to their new article here: https://authors.elsevier.com/a/1V8Lr3AkHAI6DS.
Science Daily News
- Your morning coffee could secretly be weakening antibiotics September 11, 2025Researchers have discovered that everyday substances like caffeine can influence how bacteria such as E. coli respond to antibiotics. By examining 94 common drugs and food ingredients, scientists found that certain compounds trigger genetic regulators that control bacterial transport proteins, altering what gets inside the cells. In the case of caffeine, this led to reduced […]
- Hubble just captured a glittering star cluster like no other September 11, 2025Hubble’s latest image captures a glittering star cluster inside the Large Magellanic Cloud, a dwarf galaxy about 160,000 light-years from Earth. This region, known as N11, is one of the galaxy’s largest stellar nurseries where vast clouds of gas and dust give birth to new stars.
- Blocked blood flow makes cancer grow faster September 11, 2025Researchers at NYU Langone Health discovered that cutting off blood flow accelerates cancer growth by prematurely aging the bone marrow and weakening the immune system. In mouse models, restricted blood flow doubled the growth rate of breast tumors, mimicking changes seen during aging. The study found that ischemia reprograms bone marrow stem cells, skewing the […]
- This rare white dwarf looks normal, until Hubble shows its explosive secret September 11, 2025Hubble has uncovered a rare ultra-massive white dwarf created in a violent star merger. Once thought to be ordinary, the star’s ultraviolet signature revealed its explosive history and hinted that such cosmic collisions may be surprisingly common.
- NASA’s celestial “Accident” unlocks secrets of Jupiter and Saturn September 11, 2025Astronomers studying an oddball brown dwarf called “The Accident” have finally spotted silane, a long-predicted silicon molecule missing from Jupiter and Saturn’s skies. Its ancient, oxygen-poor atmosphere allowed the molecule to form, offering new insight into how planetary atmospheres evolve.