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Recent Article Published: Unique H-bonding of Adenine with oxidatively damaged base 8-oxoguanosine enables specific recognition and repair by DNA glycosylase MutY.
Recent Article Published by Sheila David’s Lab: Unique Hydrogen Bonding of Adenine with the Oxidatively Damaged Base 8-Oxoguanine Enables Specific Recognition and Repair by DNA Glycosylase MutY. Majumdar, C.; Mckibbin, P.L.; Krajewski, A.E.; Manlove, A.H.; Lee, J.K.; David, S.S. J. Am. Soc. 2020. 142, 48, 20340–20350. DNA repair protein MutY employs specific […]
New Manuscript Published: The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair.
New Manuscript Published: The Zinc Linchpin Motif in the DNA Repair Glycosylase MUTYH: Identifying the Zn2+ Ligands and Roles in Damage Recognition and Repair. A recent publication from the David, Siegel and Lim (Academia Sinica, Taiwan) labs (Nuñez et al., JACS, 2018) provides insight into the coordination sphere and critical role of a Zn2+ metal […]
Just Accepted Manuscript: Structure Activity Relationships Reveal Key Features of 8-Oxoguanine:Adenine Mismatch Detection by the MutY DNA Glycosylase
7/20/2017 The recently accepted manuscript, Structure Activity Relationships Reveal Key Features of 8-Oxoguanine:Adenine Mismatch Detection by the MutY DNA Glycosylase, was accepted for publication in ACS Chemical Biology. MutY, remarkably, is able to specifically recognize and initiate repair of target OG:A mismatches from among a vast sea of natural DNA. To help reveal molecular features of […]
Congratulations to Doug Banda and coworkers!
5/31/2017 Congratulations to David Lab authors Doug, Nicole, Michael, and Katie on their recently released article, “Repair of 8-OXOG:A Mismatches by the MUTYH Glycosylase: Mechanisms, Metals and Medicine,” in Free Radical Biology and Medicine! The final version of the article is now available online. Link to their new article here: https://authors.elsevier.com/a/1V8Lr3AkHAI6DS.
Science Daily News
- Scientists discover armored “goblin monster” in prehistoric Utah August 29, 2025Scientists have identified a new giant lizard, Bolg amondol, from Utah’s Kaiparowits Formation, named after Tolkien’s goblin prince. Part of the monstersaur lineage, Bolg reveals that multiple large lizards coexisted with dinosaurs, suggesting a thriving ecosystem. Its discovery in long-stored fossils underscores how museums hold hidden scientific gems.
- 70-million-year-old crocodile relative with dinosaur-crushing jaws found in Argentina August 29, 2025Seventy million years ago, southern Patagonia was home to dinosaurs, turtles, and mammals—but also to a fierce crocodile-like predator. A newly discovered fossil, astonishingly well-preserved, reveals Kostensuchus atrox, a powerful 3.5-meter-long apex predator with crushing jaws and sharp teeth capable of devouring medium-sized dinosaurs. As one of the largest hunters of its time and the […]
- Scientists create scalable quantum node linking light and matter August 29, 2025Quantum scientists in Innsbruck have taken a major leap toward building the internet of the future. Using a string of calcium ions and finely tuned lasers, they created quantum nodes capable of generating streams of entangled photons with 92% fidelity. This scalable setup could one day link quantum computers across continents, enable unbreakable communication, and […]
- A strange quantum effect could power future electronics August 29, 2025Rice University physicists confirmed that flat electronic bands in kagome superconductors aren’t just theoretical, they actively shape superconductivity and magnetism. This breakthrough could guide the design of next-generation quantum materials and technologies.
- Scientists finally solve a century-old quantum mystery August 29, 2025A Vermont research team has cracked a 90-year-old puzzle, creating a quantum version of the damped harmonic oscillator. By reformulating Lamb’s classical model, they showed how atomic vibrations can be fully described while preserving quantum uncertainty. The discovery could fuel next-generation precision tools.